4.6 Article

CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma

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Article Multidisciplinary Sciences

SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice

Veronica Moncho-Amor et al.

Summary: The study reveals the role of SOX2 in endocrine tumorigenesis in p27(-/-) pituitaries, showing that increased levels of SOX2 in both endocrine and stem cells are associated with pituitary hyperplasia. SOX2 is required cell autonomously in endocrine cells for tumor formation and in stem cells for promotion of tumorigenesis. Single cell transcriptomic analysis further highlights the importance of the SOX2-dependent MAPK pathway in stem cells for tumorigenesis.

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