期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/jcm10091933
关键词
critical care; hemodialysis; death; sudden; cardiac; electrocardiography; kidney failure; arrhythmias
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1E1A1A01078382]
- Korea Medical Device Development Fund - Korea government (Ministry of Science and ICT) [202011B26]
- Korea Medical Device Development Fund - Korea government (Ministry of Trade, Industry and Energy) [202011B26]
- Korea Medical Device Development Fund - Korea government (Ministry of Health Welfare) [202011B26]
- Korea Medical Device Development Fund - Korea government (Ministry of Food and Drug Safety) [202011B26]
The rate of sudden cardiac death is significantly higher in hemodialysis patients, with QTpe interval and ECG parameters being potential predictors for predicting SCD risk in this population.
The rate of sudden cardiac death (SCD) for hemodialysis (HD) patients is significantly higher than that observed in the general population and have the highest risk for arrhythmogenic death. In this multi-center study, patients starting hemodialysis in each hospital were enrolled; they underwent regular check-ups in an open-patient clinic. We examined serial electrocardiography (ECG) data in patients undergoing HD and determined their associations with the occurrence of SCD. Of 678 enrolled subjects who underwent serial ECG before and after hemodialysis, 291 died and 39 developed SCD. In all subjects, the QT peak-to-end (QTpe) interval at all leads and QRS duration were shortened after hemodialysis. The SCD group showed a significant change in the QTpe interval of the inferior, anterior, and lateral leads before and after hemodialysis compared with the survivor group (p < 0.001). In the pre-hemodialysis ECG, SCD patients had significantly longer QTpe intervals in all leads (p < 0.001) and a longer QRS duration (92.6 +/- 14.0 vs. 100.6 +/- 14.9 ms, p = 0.015) than survivors. In conclusion, patients with a longer QTpe interval before hemodialysis and large changes in ECG parameters after hemodialysis might be at a higher risk of SCD. Therefore, changes in the ECG before and after hemodialysis could help to predict SCD.
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