4.7 Review

A Roadmap of In Vitro Models in Osteoarthritis: A Focus on Their Biological Relevance in Regenerative Medicine

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Orthopedics

Micro-fragmentation is a valid alternative to cell expansion and enzymatic digestion of adipose tissue for the treatment of knee osteoarthritis: a comparative preclinical study

Giuseppe Filardo et al.

Summary: The study compared three procedures for treating osteoarthritis using adipose-derived cells. Mechanical micro-fragmentation (MF) showed the most promising results in protecting the articular surface from OA processes.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2022)

Review Endocrinology & Metabolism

Models of Osteoarthritis: Relevance and New Insights

Hasmik Jasmine Samvelyan et al.

Summary: Osteoarthritis is a common musculoskeletal disease characterized by cartilage degradation and osteophyte formation. While 2D in vitro models are cost-effective, they do not represent physiological conditions. Recent studies have utilized 3D tissue models to mimic physiological conditions and investigate additional variables.

CALCIFIED TISSUE INTERNATIONAL (2021)

Article Multidisciplinary Sciences

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis

Carola Cavallo et al.

Summary: This study highlights the potential impact of sEV derived from adipose tissue on gene expression and protein release of chondrocytes and synoviocytes, as well as their ability to attenuate the inflammatory/catabolic environment mediated by the NF-kappa B pathway, offering a promising new therapeutic strategy for addressing osteoarthritis.

SCIENTIFIC REPORTS (2021)

Review Pharmacology & Pharmacy

Osteoarthritis In Vitro Models: Applications and Implications in Development of Intra-Articular Drug Delivery Systems

Carlota Salgado et al.

Summary: OA in vitro models play a crucial role in the development of IA formulation, offering insights into molecular pathways, drug interactions, cytotoxicity assessments, and in vivo predictions. However, improvements are needed in understanding the intricacies of cellular models for a more accurate representation of in vivo conditions in 2D and 3D contexts.

PHARMACEUTICS (2021)

Article Orthopedics

Osteoarthritic Milieu Affects Adipose-Derived Mesenchymal Stromal Cells

Cristina Manferdini et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2020)

Article Rheumatology

Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses

Hannah Labinsky et al.

ARTHRITIS & RHEUMATOLOGY (2020)

Review Biochemistry & Molecular Biology

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Xing-Liang Fan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Review Cell Biology

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Antoniana Batsivari et al.

NATURE CELL BIOLOGY (2020)

Review Orthopedics

Extracellular vesicles: Potential role in osteoarthritis regenerative medicine

Xiaoxin Wu et al.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2020)

Review Chemistry, Multidisciplinary

New Insights on Mechanical Stimulation of Mesenchymal Stem Cells for Cartilage Regeneration

Silvia Ravalli et al.

APPLIED SCIENCES-BASEL (2020)

Review Biochemistry & Molecular Biology

Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis

Laura Gambari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cell & Tissue Engineering

Regenerative Therapy for Osteoarthritis: A Perspective

Gun-Il Im et al.

INTERNATIONAL JOURNAL OF STEM CELLS (2020)

Article Biochemistry & Molecular Biology

Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis

Agnes Schroeder et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Rheumatology

Active viscosupplements for osteoarthritis treatment

Gloria Maria Pontes-Quero et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2019)

Article Cell & Tissue Engineering

A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment

Robert M. Stefani et al.

TISSUE ENGINEERING PART A (2019)

Review Immunology

M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds

Youhan Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Regenerative Features of Adipose Tissue for Osteoarthritis Treatment in a Rabbit Model: Enzymatic Digestion Versus Mechanical Disruption

Giovanna Desando et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biotechnology & Applied Microbiology

Mimicking the Articular Joint with In Vitro Models

Susanna Piluso et al.

TRENDS IN BIOTECHNOLOGY (2019)

Review Cell Biology

NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction

Moon-Chang Choi et al.

Review Cell Biology

Articular Cartilage Regeneration in Osteoarthritis

Livia Roseti et al.

Review Medical Laboratory Technology

Exosomes in inflammation and role as biomarkers

Lara Console et al.

CLINICA CHIMICA ACTA (2019)

Review Immunology

Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease?

M. H. J. van den Bosch

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2019)

Review Orthopedics

Models of osteoarthritis: the good, the bad and the promising

P. J. Cope et al.

OSTEOARTHRITIS AND CARTILAGE (2019)

Article Medicine, Research & Experimental

A Three-Dimensional Model to Study Human Synovial Pathology

Mathijs G. A. Broeren et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2019)

Article Biochemistry & Molecular Biology

Effect of Cyclic Dynamic Compressive Loading on Chondrocytes and Adipose-Derived Stem Cells Co-Cultured in Highly Elastic Cryogel Scaffolds

Chih-Hao Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Veterinary Sciences

Time-dependent changes in gene expression induced in vitro by interleukin-1β in equine articular cartilage

Maria Lofgren et al.

RESEARCH IN VETERINARY SCIENCE (2018)

Article Cell & Tissue Engineering

Short-Term Homing of Hyaluronan-Primed Cells: Therapeutic Implications for Osteoarthritis Treatment

Giovanna Desando et al.

TISSUE ENGINEERING PART C-METHODS (2018)

Review Cell & Tissue Engineering

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

Alessandro Pirosa et al.

STEM CELL RESEARCH & THERAPY (2018)

Review Sport Sciences

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis

Xiaoqian Liu et al.

BRITISH JOURNAL OF SPORTS MEDICINE (2018)

Article Medicine, Research & Experimental

Gene expression analysis of growth factor receptors in human chondrocytes in monolayer and 3D pellet cultures

Anika Witt et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)

Review Orthopedics

Chemokines and Inflammation in Osteoarthritis: Insights From Patients and Animal Models

Carla R. Scanzello

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

Article Engineering, Biomedical

Towards bioreactor development with physiological motion control and its applications

Marcus Stoffel et al.

MEDICAL ENGINEERING & PHYSICS (2017)

Article Orthopedics

Toward understanding the role of cartilage particulates in synovial inflammation

A. M. Silverstein et al.

OSTEOARTHRITIS AND CARTILAGE (2017)

Review Cell Biology

MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis

Stefania D'Adamo et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Cell & Tissue Engineering

A Three-Dimensional Chondrocyte-Macrophage Coculture System to Probe Inflammation in Experimental Osteoarthritis

Satyavrata Samavedi et al.

TISSUE ENGINEERING PART A (2017)

Review Cell & Tissue Engineering

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

Di Chen et al.

BONE RESEARCH (2017)

Review Multidisciplinary Sciences

Current perspectives on biological approaches for osteoarthritis

Kaitlyn E. Whitney et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Article Orthopedics

IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro

P. Behrendt et al.

BMC MUSCULOSKELETAL DISORDERS (2017)

Review Rheumatology

Molecular mechanisms underlying osteoarthritis development: Notch and NF-kB

Taku Saito et al.

ARTHRITIS RESEARCH & THERAPY (2017)

Review Rheumatology

Synovitis in osteoarthritis: current understanding with therapeutic implications

Alexander Mathiessen et al.

ARTHRITIS RESEARCH & THERAPY (2017)

Article Immunology

Synovial macrophage-derived IL-1β regulates the calcitonin receptor in osteoarthritic mice

S. Takano et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2016)

Review Biotechnology & Applied Microbiology

Exosomes for repair, regeneration and rejuvenation

Joydeep Basu et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

Article Cell & Tissue Engineering

Autologous Bone Marrow Concentrate in a Sheep Model of Osteoarthritis: New Perspectives for Cartilage and Meniscus Repair

Giovanna Desando et al.

TISSUE ENGINEERING PART C-METHODS (2016)

Review Veterinary Sciences

In vitro models for the study of osteoarthritis

Craig I. Johnson et al.

VETERINARY JOURNAL (2016)

Review Rehabilitation

Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments

C. Vinatier et al.

ANNALS OF PHYSICAL AND REHABILITATION MEDICINE (2016)

Review Rheumatology

State of the evidence

Kelli D. Allen et al.

CURRENT OPINION IN RHEUMATOLOGY (2015)

Review Cell Biology

Targets, models and challenges in osteoarthritis research

Sarah Thysen et al.

DISEASE MODELS & MECHANISMS (2015)

Review Cell Biology

Forcing cells into shape: the mechanics of actomyosin contractility

Michael Murrell et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Editorial Material Orthopedics

Inflammation in osteoarthritis: changing views

F. Berenbaum et al.

OSTEOARTHRITIS AND CARTILAGE (2015)

Review Orthopedics

Metabolic triggered inflammation in osteoarthritis

X. Wang et al.

OSTEOARTHRITIS AND CARTILAGE (2015)

Article Cell & Tissue Engineering

Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint

Niamh Fahy et al.

TISSUE ENGINEERING PART B-REVIEWS (2015)

Article Rheumatology

Voltage-Dependent Calcium Channels in Chondrocytes: Roles in Health and Disease

Csaba Matta et al.

CURRENT RHEUMATOLOGY REPORTS (2015)

Review Rheumatology

Emerging regulators of the inflammatory process in osteoarthritis

Ru Liu-Bryan et al.

NATURE REVIEWS RHEUMATOLOGY (2015)

Article Orthopedics

Preclinical models for in vitro mechanical loading of bone-derived cells

Robin Michael Delaine-Smith et al.

BONEKEY REPORTS (2015)

Article Pharmacology & Pharmacy

Mitochondrial Pathology in Osteoarthritic Chondrocytes

Longhuo Wu et al.

CURRENT DRUG TARGETS (2014)

Review Pharmacology & Pharmacy

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

Mohammad R. Ebrahimkhani et al.

DRUG DISCOVERY TODAY (2014)

Review Medicine, Research & Experimental

Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases

Peter G. Alexander et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2014)

Review Biochemistry & Molecular Biology

Acquiring Chondrocyte Phenotype from Human Mesenchymal Stem Cells under Inflammatory Conditions

Masahiro Kondo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Review Biochemistry & Molecular Biology

Signaling Pathways in Cartilage Repair

Erminia Mariani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Medicine, Research & Experimental

Stem Cell-Based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1β

Hang Lin et al.

MOLECULAR PHARMACEUTICS (2014)

Review Chemistry, Physical

Materials as stem cell regulators

William L. Murphy et al.

NATURE MATERIALS (2014)

Article Endocrinology & Metabolism

A new method to investigate how mechanical loading of osteocytes controls osteoblasts

Marisol Vazquez et al.

FRONTIERS IN ENDOCRINOLOGY (2014)

Review Medicine, Research & Experimental

Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians

M. Carrington Reid

ADVANCES IN THERAPY (2013)

Article Biotechnology & Applied Microbiology

Dynamic compressive loading differentially regulates chondrocyte anabolic and catabolic activity with age

Nikki. L. Farnsworth et al.

BIOTECHNOLOGY AND BIOENGINEERING (2013)

Review Endocrinology & Metabolism

Mechanosensation and transduction in osteocytes

Jenneke Klein-Nulend et al.

Review Cell & Tissue Engineering

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

Maria Ester Bernardo et al.

CELL STEM CELL (2013)

Article Rheumatology

Aggrecanases in the human synovial fluid at different stages of osteoarthritis

Enshui Zhang et al.

CLINICAL RHEUMATOLOGY (2013)

Article Biochemical Research Methods

Chemokine and cytokine levels in osteoarthritis and rheumatoid arthritis synovial fluid

Ulrike Hampel et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2013)

Review Orthopedics

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

F. Berenbaum

OSTEOARTHRITIS AND CARTILAGE (2013)

Article Orthopedics

The epidemiology and impact of pain in osteoarthritis

T. Neogi

OSTEOARTHRITIS AND CARTILAGE (2013)

Article Cell & Tissue Engineering

Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis

Marie Maumus et al.

STEM CELL RESEARCH (2013)

Review Biotechnology & Applied Microbiology

Engineering Parameters in Bioreactor's Design: A Critical Aspect in Tissue Engineering

Nasim Salehi-Nik et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Endocrinology & Metabolism

Addressing the gaps: sex differences in osteoarthritis of the knee

Barbara D. Boyan et al.

BIOLOGY OF SEX DIFFERENCES (2013)

Review Rheumatology

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

Jeremy Sokolove et al.

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2013)

Review Rheumatology

Osteoarthritis: A disease of the joint as an organ

Richard F. Loeser et al.

ARTHRITIS AND RHEUMATISM (2012)

Article Biophysics

Mechanics of chondrocyte hypertrophy

C. C. van Donkelaar et al.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2012)

Review Endocrinology & Metabolism

The role of synovitis in osteoarthritis pathogenesis

Carla R. Scanzello et al.

Article Dentistry, Oral Surgery & Medicine

Prolonged matrix metalloproteinase-3 high expression after cyclic compressive load on human synovial cells in three-dimensional cultured tissue

Y. Akamine et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2012)

Review Engineering, Biomedical

Functional biomaterials for cartilage regeneration

Zigang Ge et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2012)

Article Orthopedics

Zonal differences in meniscus matrix turnover and cytokine response

E. S. Fuller et al.

OSTEOARTHRITIS AND CARTILAGE (2012)

Review Biotechnology & Applied Microbiology

Recent advances in bone tissue engineering scaffolds

Susmita Bose et al.

TRENDS IN BIOTECHNOLOGY (2012)

Review Physiology

Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy

Serena Rubina Baglio et al.

FRONTIERS IN PHYSIOLOGY (2012)

Article Orthopedics

Physical Stimulation of Chondrogenic Cells In Vitro: A Review

Sibylle Grad et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2011)

Article Cell & Tissue Engineering

Mechanical Properties of Natural Cartilage and Tissue-Engineered Constructs

Christopher James Little et al.

TISSUE ENGINEERING PART B-REVIEWS (2011)

Article Cell & Tissue Engineering

Hydrogels for the Repair of Articular Cartilage Defects

Kara L. Spiller et al.

TISSUE ENGINEERING PART B-REVIEWS (2011)

Article Rheumatology

The role of biomechanics in the initiation and progression of OA of the knee

Martin Englund

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2010)

Article Biotechnology & Applied Microbiology

Chondrogenic differentiation of human mesenchymal stem cells: a comparison between micromass and pellet culture systems

Liangming Zhang et al.

BIOTECHNOLOGY LETTERS (2010)

Review Developmental Biology

The Role of Mechanical Signals in Regulating Chondrogenesis and Osteogenesis of Mesenchymal Stem Cells

Daniel J. Kelly et al.

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS (2010)

Review Multidisciplinary Sciences

Cell mechanics and the cytoskeleton

Daniel A. Fletcher et al.

NATURE (2010)

Review Rheumatology

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

Jeremie Sellam et al.

NATURE REVIEWS RHEUMATOLOGY (2010)

Article Orthopedics

Mechanical impact induces cartilage degradation via mitogen activated protein kinases

L. Ding et al.

OSTEOARTHRITIS AND CARTILAGE (2010)

Review Chemistry, Medicinal

Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks

Inger L. Meek et al.

PHARMACEUTICALS (2010)

Review Rheumatology

Cartilage in normal and osteoarthritis conditions

Johanne Martel-Pelletier et al.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2008)

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Review Cell Biology

Osteoarthritis

Mary B. Goldring et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2007)

Article Engineering, Multidisciplinary

A critical review on polymer-based bio-engineered materials for scaffold development

Hoi-Yan Cheung et al.

COMPOSITES PART B-ENGINEERING (2007)

Article Cell & Tissue Engineering

Il-1β and BMPS -: Interactive players of cartilage matrix degradation and regeneration

Thomas Aigner et al.

EUROPEAN CELLS & MATERIALS (2006)

Review Biotechnology & Applied Microbiology

Bioreactors for tissue engineering

Huang-Chi Chen et al.

BIOTECHNOLOGY LETTERS (2006)

Article Orthopedics

A low temperature method of isolating normal human articular chondrocytes

NC Hidvegi et al.

OSTEOARTHRITIS AND CARTILAGE (2006)

Review Biotechnology & Applied Microbiology

Bioreactor-based engineering of osteochondral grafts: from model systems to tissue manufacturing

D Wendt et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2005)

Review Engineering, Biomedical

Mechanobiology in the third dimension

JA Pedersen et al.

ANNALS OF BIOMEDICAL ENGINEERING (2005)

Review Neurosciences

Role of the immune system in chronic pain

F Marchand et al.

NATURE REVIEWS NEUROSCIENCE (2005)

Article Engineering, Biomedical

Integrin-dependent signal cascades in chondrocyte mechanotransduction

SJ Millward-Sadler et al.

ANNALS OF BIOMEDICAL ENGINEERING (2004)

Article Orthopedics

The role of cytokines in cartilage matrix degeneration in osteoarthritis

SR Goldring et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2004)

Article Engineering, Biomedical

Biomechanical strategies for articular cartilage regeneration

EM Darling et al.

ANNALS OF BIOMEDICAL ENGINEERING (2003)

Article Orthopedics

Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts

SK Williams et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2003)

Article Rheumatology

Stem cell therapy in a caprine model of osteoarthritis

JM Murphy et al.

ARTHRITIS AND RHEUMATISM (2003)

Review Rheumatology

The stressed synovium

G Schett et al.

ARTHRITIS RESEARCH (2001)

Article Biochemistry & Molecular Biology

Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity

MZ Ilic et al.

MATRIX BIOLOGY (2000)