期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/jcm10081738
关键词
constipation; chronic constipation; pharmacology; surgery; clinical management
资金
- NCN-Diamentowy Grant [504/5-120-02/504-11-014]
- Medical University of Lodz [503/1-156-04/503-11-001-19-00]
Constipation is a major gastrointestinal disorder in Western countries, affecting almost 20% of the population. The pathophysiology is complex and multifactorial, making diagnosis and treatment challenging. Both nonpharmacological and pharmacological approaches are used, with surgery being a potential solution for refractory cases.
Constipation is one of the major gastrointestinal disorders diagnosed in clinical practice in Western countries. Almost 20% of population suffer from this disorder, which means constipation is a substantial utilization of healthcare. Pathophysiology of constipation is complex and multifactorial, where aspects like disturbance in colonic transit, genetic predisposition, lifestyle habits, psychological distress, and many others need to be taken into consideration. Diagnosis of constipation is troublesome and requires thorough accurate examination. A nonpharmacological approach, education of the patient about the importance of lifestyle changes like diet and sport activity state, are the first line of therapy. In case of ineffective treatment, pharmacological treatments such as laxatives, secretagogues, serotonergic agonists, and many other medications should be induced. If pharmacologic treatment fails, the definitive solution for constipation might be surgical approach. Commonness of this disorder, costs of medical care and decrease in quality life cause constipation is a serious issue for many specialists. The aim of this review is to present current knowledge of chronic constipation and management of this disorder.
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