期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/jcm10081754
关键词
seizure; epilepsy; benzodiazepines; routes of administration; status epilepticus; repetitive seizures; cluster seizures; acute repetitive seizure
资金
- National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) [90AR5025]
- NIDILRR [90AR5025, 809814] Funding Source: Federal RePORTER
Time is crucial in the evaluation and treatment of seizures. Acute repetitive seizures and status epilepticus are medical emergencies that require immediate assessment and treatment for optimal therapeutic response. Benzodiazepines are considered first-line agents for rapid seizure control, but choosing the right route of administration is key.
Time plays a major role in seizure evaluation and treatment. Acute repetitive seizures and status epilepticus are medical emergencies that require immediate assessment and treatment for optimal therapeutic response. Benzodiazepines are considered the first-line agent for rapid seizure control. Thus, various routes of administration of benzodiazepines have been studied to facilitate a quick, effective, and easy therapy administration. Choosing the right agent may vary based on the drug and route properties, patient's environment, caregiver's skills, and drug accessibility. The pharmacokinetic and pharmacodynamic aspects of benzodiazepines are essential in the decision-making process. Ultimately, agents and routes that give the highest bioavailability, fastest absorption, and a modest duration are preferred. In the outpatient setting, intranasal and buccal routes appear to be equally effective and more rapidly administered than rectal diazepam. On the other hand, in the inpatient setting, if available, the IV route is ideal for benzodiazepine administration to avoid any potential absorption delay. In this article, we will provide an overview and comparison of the various routes of benzodiazepine administration for acute control of repetitive seizures and status epilepticus.
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