4.7 Article

A Comparison of the Correlation of Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) with Health-Related Quality of Life

期刊

JOURNAL OF CLINICAL MEDICINE
卷 10, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/jcm10102137

关键词

systemic lupus erythematosus; quality of life; cross-sectional studies; surveys and questionnaires

资金

  1. Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan [DTCRD109-I-21, DTCRD109-I-23]
  2. Buddhist Tzu Chi Medical Foundation, Taiwan [TCMF-A 108-05]

向作者/读者索取更多资源

This study compared the correlation of SLE-DAS and SLEDAI-2K with LupusQoL in Taiwanese patients with SLE, showing no clear differences in assessing HRQoL. Both SLEDAI-2K and SLE-DAS were found to be effective tools for measuring disease activity in patients with SLE.
Background and Aim: The aim of this study was to compare the correlation of a recently developed systemic lupus erythematosus disease activity score (SLE-DAS) with the SLE disease activity index 2000 (SLEDAI-2K) with the Lupus Quality of Life questionnaire (LupusQoL) in Taiwanese patients with SLE. Methods: A cross-sectional study was conducted in a regional teaching hospital in Taiwan from April to August 2019. Adult patients with a clinician-confirmed diagnosis of SLE based on the 1997 American College of Rheumatology revised criteria or the 2012 Systemic Lupus International Collaborating Clinics Classification Criteria were recruited. SLE disease activity was measured with both SLEDAI-2K and SLE-DAS. Disease-specific quality of life was assessed using the LupusQoL. Results: Of the 333 patients with SLE in this study, 90.4% were female and 40% were between the ages of 20 and 39 years. The median SLEDAI-2K score was 4.00 (interquartile range [IQR] 2.00-7.50) and the median SLE-DAS score was 2.08 (IQR 1.12-8.24) in our patients with SLE. After adjusting for sex and age intervals, both SLEDAI-2k and SLE-DAS were significantly and inversely associated with all eight domains of LupusQoL. The magnitudes of the mean absolute error, root mean square error, Akaike Information Criterion, Bayesian Information Criterion, and coefficient of determination were comparable between SLEDAI-2K and SLE-DAS. Conclusions: There were no clear differences in the use of SLE-DAS over SLEDAI-2K in assessing HRQoL in patients with SLE. We suggest that, in this aspect, both SLEDAI-2K and SLE-DAS are effective tools for measuring disease activity in patients with SLE.

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