期刊
ACTA PHARMACEUTICA SINICA B
卷 11, 期 7, 页码 1978-1992出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2021.03.035
关键词
Synergistic immunotherapy; Post-surgical tumor recurrence; Theranostics; Gold nanorods; Phototherapy; Lung metastasis; Fluorescence resonance energy transfer; Carcinoembryonic antigen
资金
- National Key Research and Development Program of China [2017YFA0205104, 2019YFA0906500]
- National Natural Science Foundation of China [51873150, 31971300, 817719709]
- Tianjin Natural Science Foundation [19JCYBJC28800]
- Key project of Tianjin Foundational Research (JingJinJi) Program, China [19JCZDJC64100]
- Young Elite Scientists Sponsorship Program by Tianjin
The study presents an efficient synergistic immunotherapy based on gold nanorods platform for early diagnosis and treatment of post-surgical tumor recurrence. By incorporating fluorescence resonance energy transfer (FRET) technology and photothermal therapy (PTT), this approach showed promising results in inducing tumor cell death and increasing T-lymphocytes generation. The synergistic immunotherapy strategy also led to higher secretion of immune factors compared to mono-immunotherapy, providing a new perspective for basic and clinical research in the field.
Tumor recurrence after surgery is the main cause of treatment failure. However, the initial stage of recurrence is not easy to detect, and it is difficult to cure in the late stage. In order to improve the life quality of postoperative patients, an efficient synergistic immunotherapy was developed to achieve early diagnosis and treatment of post-surgical tumor recurrence, simultaneously. In this paper, two kinds of theranostic agents based on gold nanorods (AuNRs) platform were prepared. AuNRs and quantum dots (QDs) in one agent was used for the detection of carcinoembryonic antigen (CEA), using fluorescence resonance energy transfer (FRET) technology to indicate the occurrence of in situ recurrence, while AuNRs in the other agent was used for photothermal therapy (PTT), together with anti-PDL1 mediated immunotherapy to alleviate the process of tumor metastasis. A series of assays indicated that this synergistic immunotherapy could induce tumor cell death and the increased generation of CD3(+)/CD4(+) T-lymphocytes and CD3(+)/CD8(+) T-lymphocytes. Besides, more immune factors (IL-2, IL-6, and IFN-gamma) produced by synergistic immunotherapy were secreted than mono-immunotherapy. This cooperative immunotherapy strategy could be utilized for diagnosis and treatment of postoperative tumor recurrence at the same time, providing a new perspective for basic and clinical research. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据