期刊
EBIOMEDICINE
卷 66, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2021.103341
关键词
Cytokine storm; COVID-19; HERV-W; human endogenous retroviruses; Inflammation; Respiratory outcome; T-cell exhaustion
资金
- Geneuro innovation
The study analyzed the expression of HERV-W ENV in the blood of COVID-19 patients, finding that it was highly expressed in patients' leukocytes and correlated with markers of T-cell differentiation, exhaustion, blood cytokine levels, inflammatory markers, and pneumonia severity. HERV-W ENV expression also reflected the respiratory outcome of patients during hospitalization, suggesting its potential as a biomarker for predicting disease progression and as a target for further therapeutic interventions.
Background: Despite an impressive effort in clinical research, no standard therapeutic approach for coronavirus disease 2019 (COVID-19) patients has been established, highlighting the need to identify early biomarkers for predicting disease progression and new therapeutic interventions for patient management. The present study aimed to evaluate the involvement of the human endogenous retrovirus -W envelope (HERVW ENV) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection considering recent findings that HERVs are activated in response to infectious agents and lead to various immunopathological effects. We analysed HERV-W ENV expression in blood cells of COVID-19 patients in correlation with clinical characteristics and have discussed its potential role in the outcome of the disease. Methods: We analysed HERV-W ENV expression in blood samples of COVID-19 patients and healthy donors by flow cytometry and quantitative reverse transcriptase PCR analysis, and evaluated its correlation with clinical signs, inflammatory markers, cytokine expression, and disease progression. Findings: HERV-W ENV was highly expressed in the leukocytes of COVID-19 patients but not in those of healthy donors. Its expression correlated with the markers of T-cell differentiation and exhaustion and blood cytokine levels. The percentage of HERV-W ENV-positive lymphocytes correlated with inflammatory markers and pneumonia severity in COVID-19 patients. Notably, HERV-W ENV expression reflects the respiratory outcome of patients during hospitalization. Interpretation: Given the known immuno- and neuro-pathogenicity of HERV-W ENV protein, it could promote certain pathogenic features of COVID-19 and therefore serve as a biomarker to predict clinical progression of disease and open to further studies for therapeutic intervention. (C) 2021 The Author(s). Published by Elsevier B.V.
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