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Shaoyong Lu et al.
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Benjamin Merget et al.
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Fiona Tsui-Fen Cheng et al.
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Howook Hwang et al.
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Yunan Luo et al.
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Anna Cichonska et al.
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Xing Chen et al.
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Zichen Wang et al.
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Hassan Al-Ali et al.
ACS CHEMICAL BIOLOGY (2015)
An integrated structure- and system-based framework to identify new targets of metabolites and known drugs
Hammad Naveed et al.
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Finding optimal interaction interface alignments between biological complexes
Xuefeng Cui et al.
BIOINFORMATICS (2015)
FDA-approved small-molecule kinase inhibitors
Peng Wu et al.
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Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function
V. Felzen et al.
CELL DEATH & DISEASE (2015)
Comprehensive prediction of drug-protein interactions and side effects for the human proteome
Hongyi Zhou et al.
SCIENTIFIC REPORTS (2015)
UniProt: a hub for protein information
Alex Bateman et al.
NUCLEIC ACIDS RESEARCH (2015)
Similarity-based machine learning methods for predicting drug-target interactions: a brief review
Hao Ding et al.
BRIEFINGS IN BIOINFORMATICS (2014)
Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies
Chong Sun et al.
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Molecularly targeted cancer therapy: some lessons from the past decade
Min Huang et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Risk factors for sorafenib-induced high-grade skin rash in Japanese patients with advanced renal cell carcinoma
Norihiko Tsuchiya et al.
ANTI-CANCER DRUGS (2013)
Drug Target Prediction and Repositioning Using an Integrated Network-Based Approach
Dorothea Emig et al.
PLOS ONE (2013)
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
Ulrich M. Zanger et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Drug repositioning: a machine-learning approach through data integration
Francesco Napolitano et al.
JOURNAL OF CHEMINFORMATICS (2013)
Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome
Chun-Yu Wei et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)
A Strategy Based on Protein-Protein Interface Motifs May Help in Identifying Drug Off-Targets
H. Billur Engin et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Large-scale prediction and testing of drug activity on side-effect targets
Eugen Lounkine et al.
NATURE (2012)
Use of genome-wide association studies for drug repositioning
Philippe Sanseau et al.
NATURE BIOTECHNOLOGY (2012)
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
David A. Ostrov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Structural approaches to obtain kinase selectivity
Richard A. Norman et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
DECK: Distance and environment-dependent, coarse-grained, knowledge-based potentials for protein-protein docking
Shiyong Liu et al.
BMC BIOINFORMATICS (2011)
Principles of early drug discovery
J. P. Hughes et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Structural Signatures of Enzyme Binding Pockets from Order-Independent Surface Alignment: A Study of Metalloendopeptidase and NAD Binding Proteins
Joe Dundas et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Comprehensive analysis of kinase inhibitor selectivity
Mindy I. Davis et al.
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Phase II failures: 2008-2010
John Arrowsmith
NATURE REVIEWS DRUG DISCOVERY (2011)
TRIAL WATCH Phase III and submission failures: 2007-2010
John Arrowsmith
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A Computational Approach to Finding Novel Targets for Existing Drugs
Yvonne Y. Li et al.
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Extranuclear Functions of ER Impact Invasive Migration and Metastasis by Breast Cancer Cells
Dimple Chakravarty et al.
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Nuclear Targeting of Cyclin-Dependent Kinase 2 Reveals Essential Roles of Cyclin-Dependent Kinase 2 Localization and Cyclin E in Vitamin D-Mediated Growth Inhibition
Omar Flores et al.
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A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias
K. W. Pratz et al.
LEUKEMIA (2010)
Discovery of drug mode of action and drug repositioning from transcriptional responses
Francesco Iorio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
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Roger L. Chang et al.
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Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets
Silpa Suthram et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
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Xiaoyan A. Qu et al.
BMC BIOINFORMATICS (2009)
Novel Agents on the Horizon for Cancer Therapy
Wen W. Ma et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2009)
The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Simak Ali et al.
CANCER RESEARCH (2009)
Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters
Shuiying Hu et al.
CLINICAL CANCER RESEARCH (2009)
Predicting new molecular targets for known drugs
Michael J. Keiser et al.
NATURE (2009)
Human Disease-Drug Network Based on Genomic Expression Profiles
Guanghui Hu et al.
PLOS ONE (2009)
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
Madeleine M. Hipp et al.
BLOOD (2008)
A quantitative analysis of kinase inhibitor selectivity
Mazen W. Karaman et al.
NATURE BIOTECHNOLOGY (2008)
Drug target identification using side-effect similarity
Monica Campillos et al.
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Identification and functional signature of genes regulated by structurally different ABL kinase inhibitors
K. Nunoda et al.
ONCOGENE (2007)
Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer
V. Craig Jordan et al.
STEROIDS (2007)
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
Guo Wei et al.
CANCER CELL (2006)
CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues
Joe Dundas et al.
NUCLEIC ACIDS RESEARCH (2006)
PISCES: recent improvements to a PDB sequence culling server
GL Wang et al.
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Elucidating mechanisms of drug-induced toxicity
DC Liebler et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Protein kinase inhibitors: Insights into drug design from structure
MEM Noble et al.
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The MHC class I antigen presentation pathway: strategies for viral immune evasion
EW Hewitt
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Structural basis for control by phosphorylation
LN Johnson et al.
CHEMICAL REVIEWS (2001)
Kinetic and catalytic mechanisms of protein kinases
JA Adams
CHEMICAL REVIEWS (2001)
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