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Immune profiling of COVID-19: preliminary findings and implications for the pandemic

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Immunology

Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Kai Wang et al.

Summary: This study found that specific neutralizing antibody titers against SARS-CoV-2 in patients with COVID-19 were initially low in the first 7-10 days after symptom onset, then gradually increased and peaked at 2-3 weeks. The titers of neutralizing antibodies and IgG levels showed a positive correlation over time, and were also significantly correlated with levels of proinflammatory cytokines.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Cardiac & Cardiovascular Systems

Usefulness of Elevated Troponin to Predict Death in Patients With COVID-19 and Myocardial Injury

David T. Majure et al.

Summary: "Elevated troponin levels in COVID-19 patients are associated with increased mortality, independent of inflammation and cardiovascular co-morbidities."

AMERICAN JOURNAL OF CARDIOLOGY (2021)

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Review Infectious Diseases

Epidemiology of SARS-CoV-2

Bernd Salzberger et al.

Summary: SARS-CoV-2 primarily spreads through droplets and aerosols, with most infections being uncomplicated but 5-10% of patients requiring hospitalization, mainly due to respiratory and multiorgan failure. Risk factors for complications include older age, hypertension, diabetes, chronic cardiovascular disease, etc. Various countries have implemented strict control measures resulting in low attack rates.

INFECTION (2021)

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Review Cell Biology

Aging in COVID-19: Vulnerability, immunity and intervention

Yiyin Chen et al.

Summary: The COVID-19 pandemic originating from Wuhan in December 2019 has had far-reaching health and socioeconomic impacts worldwide. The disease caused by SARS-CoV-2 is highly heterogeneous, with age, gender, and comorbidities playing key roles in disease severity and outcomes. Aging and dysregulation of immune function are thought to contribute to the increased vulnerability of older adults to severe COVID-19. Further research on immune responses to SARS-CoV-2 infection, particularly in different age groups, is crucial for understanding disease heterogeneity and developing effective vaccines.

AGEING RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Lauren B. Rodda et al.

Summary: The study found that individuals recovered from mild COVID-19 develop sustained SARS-CoV-2-specific immunological memory for at least 3 months, including immunoglobulin antibodies, neutralizing plasma, and memory B and T cells. These memory lymphocytes exhibit potent antiviral function, aiding in immune defense.

CELL (2021)

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Article Biochemical Research Methods

A streamlined whole blood CyTOF workflow defines a circulating immune cell signature of COVID-19

Daniel Geanon et al.

Summary: Mass cytometry is a powerful tool for immune phenotyping, but its wide deployment is hindered by complex workflows and specialized equipment requirements. The streamlined workflow presented in this study, using commercially available reagents, addresses these challenges and enables broader adoption of CyTOF immune monitoring. The workflow allows for easy staining of whole blood samples on site, followed by batch processing at a central facility, showcasing disease-related changes in immune cells.

CYTOMETRY PART A (2021)

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Article Medicine, Research & Experimental

SARS-CoV-2-specific antibody rearrangements in prepandemic immune repertoires of risk cohorts and patients with COVID-19

Lisa Paschold et al.

Summary: This study reveals a stereotyped response of B cells to SARS-CoV-2 in COVID-19, with shared antibody sequences across different cohorts. While neutralizing antibodies were not associated with disease severity, some nonneutralizing antibodies were linked to fatal outcomes. The study also shows a restriction of B cell repertoire in aging and cancer, which may explain the varying clinical courses observed in different risk groups for COVID-19.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

A Highly Specific Assay for the Detection of SARS-CoV-2-Reactive CD4+ and CD8+ T Cells in COVID-19 Patients

Henning Zelba et al.

Summary: This study adapted a protocol for the detection of cellular immune responses against SARS-CoV-2 and successfully detected SARS-CoV-2-specific T cells in all COVID-19 patients, but not in unexposed healthy individuals.

JOURNAL OF IMMUNOLOGY (2021)

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Article Immunology

Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile

Jaclyn C. Law et al.

Summary: This study investigated T cell responses to SARS-CoV-2 in early convalescent individuals and found that while all subjects showed at least one specific T cell response, the responses were less multifunctional in severe cases compared to influenza-specific responses. CD4(+) Th1 responses predominated over CD8(+) T cell responses, had a more inflammatory profile, and showed weaker pTfh responses to SARS-CoV-2 compared to influenza virus within the same donors, potentially contributing to COVID-19 disease.

JOURNAL OF IMMUNOLOGY (2021)

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Editorial Material Infectious Diseases

Persistence of IgG response to SARS-CoV-2

Els Duysburgh et al.

LANCET INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Evolution of antibody immunity to SARS-CoV-2

Christian Gaebler et al.

Summary: After infection with SARS-CoV-2, antibody levels against the spike protein decrease significantly, but the number of memory B cells remain unchanged, indicating an evolving humoral response at 6.2 months after infection.

NATURE (2021)

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Article Immunology

Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19

Enrico Brunetta et al.

Summary: In patients with severe COVID-19, elevated levels of long pentraxin PTX3 have been found to be a strong predictor of decreased survival. Myelomonocytic cells and endothelial cells in both blood and lung tissue are major sources of PTX3, with PTX3 plasma concentration serving as an independent prognostic indicator for short-term mortality in COVID-19 patients.

NATURE IMMUNOLOGY (2021)

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Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Multidisciplinary Sciences

CD8+ T cells predicted the conversion of common covid-19 to severe

Li Liu et al.

Summary: The study revealed that lactate and CD8(+) T cells in common covid-19 patients are independent risk factors that can predict the transition from common type to severe type. The prediction model showed high consistency and accuracy in both training and validation sets, indicating the potential of CD8(+) T cells as a valuable predictor for disease progression.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

Anthony T. Tan et al.

Summary: This study found that early induction of interferon-gamma (IFN-gamma) secreting SARS-CoV-2-specific T cells was present in patients with mild disease and accelerated viral clearance, while rapid induction and quantity of humoral responses were associated with an increase in disease severity. These findings highlight the importance of early functional SARS-CoV-2-specific T cells in both vaccine design and immune monitoring.

CELL REPORTS (2021)

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Article Cell Biology

Usefulness of the New Hematological Parameter: Reactive Lymphocytes RE-LYMP with Flow Cytometry Markers of Inflammation in COVID-19

Elzbieta Rutkowska et al.

Summary: Identification of patients with activation of the immune system, especially during the COVID-19 pandemic, is crucial. This study evaluated the RE-LYMP parameter in COVID-19 patients and found correlations with activation lymphocytes markers. The study showed that COVID-19 patients had lower RE-LYMP values, higher plasmablast proportions, and lower CD4+ CD38+ cell proportions, with correlations between RE-LYMP and different activation markers in different groups.

CELLS (2021)

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An immune-based biomarker signature is associated with mortality in COVID-19 patients

Michael S. Abers et al.

Summary: Immune and inflammatory responses are important factors contributing to disease severity in COVID-19. This study identified specific immune-based biomarkers associated with mortality in COVID-19 patients, with some biomarkers consistently higher in those who died compared to those who recovered, suggesting their potential for early prediction of disease outcome.

JCI INSIGHT (2021)

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Article Biochemistry & Molecular Biology

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Xianwen Ren et al.

Summary: The study revealed the presence of immune response dysfunction in COVID-19 patients, with different peripheral immune subtype changes associated with clinical features such as age, sex, severity, and disease stages. Additionally, dramatic transcriptomic changes were observed within virus-infected cells, and upregulation of S100A8/A9 in peripheral blood may contribute to the cytokine storms frequently observed in severe patients.

CELL (2021)

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SARS-CoV-2 specific CD8+ T cell responses in convalescent COVID-19 individuals

Hassen Kared et al.

Summary: Characterization of T cell responses in convalescent individuals from SARS-CoV-2 infection revealed unique phenotypes and a coordinated immune response, with specific CD8(+) T cell responses directed against various epitopes from the virus proteome. The differentiation of T cells into stem cell and transitional memory subsets may be crucial for developing lasting protection against the virus.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Heloise Flament et al.

Summary: Severe cases of COVID-19 are characterized by immune system dysfunction, particularly a significant reduction and high activation of mucosal-associated invariant T (MAIT) cells. These cells play a crucial role in disease severity and mortality, correlating with the activation of inflammatory cytokines and cytotoxic phenotype.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration

Krista L. Newell et al.

Summary: Memory B cell frequency in convalescent COVID-19 subjects is significantly correlated with the duration of symptoms, indicating its importance as a critical indicator of disease resolution. IgM+ memory B cells may play a crucial role in SARS-CoV-2 immunity.

PLOS ONE (2021)

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Article Virology

Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients

Sebastian Deschler et al.

Summary: MAIT cells in patients with COVID-19 show high activation and expression of proinflammatory cytokines, while their antibacterial and antiviral function is impaired. The data points towards the importance of MAIT cells in the pathogenesis of COVID-19.

VIRUSES-BASEL (2021)

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Review Medical Laboratory Technology

Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19

Sarita Choudhary et al.

Summary: During the COVID-19 pandemic, understanding genetic risk factors for susceptibility to the disease is essential. Genes like ACE2, TMPRSS2, and DPP4 play key roles in determining disease severity. Research on genetic variants influencing respiratory infections can help identify potential drug targets for COVID-19 patients.

ANNALS OF LABORATORY MEDICINE (2021)

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Article Immunology

Clonal expansion and activation of tissue-resident memory-like T(H)17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Yu Zhao et al.

Summary: Hyperinflammation contributes to lung injury in severe COVID-19, with T-RM 17 cells identified as potential orchestrators of this process. High levels of IL-17A and GM-CSF were associated with a more severe clinical course in patients with COVID-19.

SCIENCE IMMUNOLOGY (2021)

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Article Immunology

Prolonged evolution of the human B cell response to SARS-CoV-2 infection

Mrunal Sakharkar et al.

Summary: The study on the kinetics and evolution of the human B cell response to SARS-CoV-2 infection revealed that serum neutralizing antibody responses declined rapidly, while spike-specific IgG(+) memory B cells remained stable or increased over time. The research also showed evidence for prolonged antibody affinity maturation and the impact of mutations in the S protein on the neutralizing antibody response.

SCIENCE IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity

Sara Falck-Jones et al.

Summary: The frequency of M-MDSCs is elevated in the blood of patients with COVID-19, suppressing T cells and strongly associated with disease severity.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Stuart P. Weisberg et al.

Summary: This study found distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts showed a broader range of antibody responses, while children predominantly generated antibodies specific for the S protein and had reduced neutralizing activity compared to adults.

NATURE IMMUNOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

Tomasz J. Guzik et al.

CARDIOVASCULAR RESEARCH (2020)

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Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

Hong-Yi Zheng et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Clinical characteristics of 3062 COVID-19 patients: A meta-analysis

Jieyun Zhu et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein

Mushtaq Hussain et al.

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Wenqing He et al.

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Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

Shufa Zheng et al.

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Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

Irani Thevarajan et al.

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Jonas Schulte-Schrepping et al.

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Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

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Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

Runhong Zhou et al.

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Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease

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Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza Patients

Linnan Zhu et al.

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Trained Innate Immunity, Epigenetics, and Covid-19

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SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential

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