4.7 Article

Higher postoperative plasma EV PD-L1 predicts poor survival in patients with gastric cancer

期刊

出版社

BMJ PUBLISHING GROUP
DOI: 10.1136/jitc-2020-002218

关键词

gastrointestinal neoplasms; immune evation

资金

  1. National Natural Science Foundation of China [30901821, 81172136, 82072737, 81201810]
  2. Natural Science Foundation of Shanxi [201701D121165, 201901D111190]
  3. Shanxi Scholarship Council of China [2020-194]
  4. International Science and Technology Cooperation Project of Shanxi Provincial Key RD Program [201703D421023]
  5. Shanxi Youth Science and Technology Research Fund [201801D221069]
  6. Open Fund from Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, China [KLMEC/SXMU202011]
  7. Shanxi '1331 Project' Key Subjects Construction [1331KSC]
  8. Shanxi Province Science Foundation for Distinguished Young Scholar [201901D211547]
  9. Science and Research Fund of Shanxi Health Commission [2019059]
  10. Doctor Project of Shanxi Cancer Hospital, China [2017A06]
  11. Key Research Project of Shanxi Province, China [201703D321010-1]
  12. Natural Science Foundation of Guangdong Province, China [2015A030313057]

向作者/读者索取更多资源

Postoperative plasma ePD-L1 level is an important prognostic indicator for gastric cancer patients after surgery, with high levels significantly correlating with poor survival, while level changes can bring significant survival benefits.
Background The satisfactory prognostic indicator of gastric cancer (GC) patients after surgery is still lacking. Perioperative plasma extracellular vesicular programmed cell death ligand-1 (ePD-L1) has been demonstrated as a potential prognosis biomarker in many types of cancers. The prognostic value of postoperative plasma ePD-L1 has not been characterized. Methods We evaluated the prognostic value of preoperative, postoperative and change in plasma ePD-L1, as well as plasma soluble PD-L1, in short-term survival of GC patients after surgery. The Kaplan-Meier survival model and Cox proportional hazards models for both univariate and multivariate analyzes were used. And the comparison between postoperative ePD-L1 and conventional serum biomarkers (carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and CA72-4) in prognostic of GC patients was made. Results The prognostic value of postoperative ePD-L1 is superior to that of preoperative ePD-L1 on GC patients after resection, and also superior to that of conventional serum biomarkers (CEA, CA19-9 and CA72-4). The levels of postoperative ePD-L1 and ePD-L1 change are independent prognostic factors for overall survival and recurrence free survival of GC patients. High plasma level of postoperative ePD-L1 correlates significantly with poor survival, while high change in ePD-L1 level brings the significant survival benefit. Conclusions The level of plasma postoperative ePD-L1 could be considered as a candidate prognostic biomarker of GC patients after resection.

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