期刊
SCIENCE ADVANCES
卷 7, 期 15, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abf6780
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资金
- NCATS NIH HHS [UL1 TR001863] Funding Source: Medline
- NIAAA NIH HHS [R00 AA026892] Funding Source: Medline
This study suggests that a ketogenic diet may help in managing alcohol withdrawal and reducing alcohol consumption by decreasing the need for benzodiazepines during withdrawal, lowering cravings for alcohol, and improving brain bioenergetics.
Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (n = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet (n = 14). Over a 3-week treatment, KD compared to SA showed lower wanting and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.
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