期刊
EUROPEAN POLYMER JOURNAL
卷 84, 期 -, 页码 236-244出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2016.09.030
关键词
Enzyme responsive; Amphiphilic diblock copolymer; Azobenzene; Self-assembly; Nitroxide-mediated radical polymerization
资金
- National Natural Science Foundation of China [21474056]
Amphiphilic diblock copolymer with an azobenzene linkage has been synthesized by the combination of macromolecular azo coupling reaction and nitroxide-mediated radical polymerization (NMP). In this strategy, an azobenzene linkage would naturally establish at the copolymer junction of the amphiphilic diblock copolymer after the macromolecular azo coupling reaction. Self-assembly of this azobenzene linked copolymer in selected solvents can result uniform self-assembly aggregates. In the presence of enzyme azoreductase and coenzyme NADPH, the amphiphilic diblock copolymer chain will be broken by the cleavage of the azobenzene linkage, which will lead to the disruption of the self-assembly aggregates. UV-vis absorption spectra measurements indicated the release of Nile red, a hydrophobic dye, encapsulated by the self-assembly aggregates. Thus, the amphiphilic diblock copolymer with azobenzene linkage can potentially be applied for the fabrication of nanocarriers for colon-specific delivery purposes applications. (C) 2016 Elsevier Ltd. All rights reserved.
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