Lewis-Acid-Mediated One-Pot Tandem Reactions for Synthesis of Structurally Diverse Furo[3,2-c]coumarins

A concise, one-pot route for the synthesis of furo[3,2-c]-coumarins under the catalysis of Zn(OTf)(2) is reported. Utilizing this synthetic strategy, libraries of furocoumarin analogues can be easily obtained by multicomponent tandem reactions with different nucleophile in the presence of 4-hydroxycoumarin and arylglyoxal monohydrate system, This transformation exhibited highly atom economical and good functional group compatibility.

Automated summary

A concise one-pot route for the synthesis of furo[3,2-c]-coumarins catalyzed by Zn(OTf)(2) has been reported, allowing for the easy generation of libraries of furocoumarin analogues through multicomponent tandem reactions. This transformation is highly atom economical and exhibits good functional group compatibility.