期刊
CHEMISTRYSELECT
卷 6, 期 14, 页码 3548-3552出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202100682
关键词
Multicomponent reaction; Strecker reaction; Sulfur; N; heterocycles; Solvent free reaction
资金
- Department of Science and Technology, DST, New Delhi [EMR/2016/002485/OC]
An efficient ABB'C four-component Strecker reaction was developed under metal- and solvent-free conditions to access N-arylidene-2-aryl-imidazo[1,2-a]azin-3-amines in high yields. This one-pot reaction using elemental sulfur as catalyst showed good tolerance to various substrates and exhibited good green chemistry metrics compared to reported methods.
An efficient ABB'C four-component Strecker reaction between 2-aminopyridines, aromatic aldehydes and trimethylsilyl cyanide (TMSCN) was developed under metal- and solvent-free conditions to access N-arylidene-2-aryl-imidazo[1,2-a]azin-3-amines in high yields. This one-pot reaction was carried out in the presence of elemental sulfur as catalyst using readily available starting material at room temperature. The reaction was tolerant to several substituted 2-aminopyridines and aryl aldehydes and have good green chemistry metrics as compared to the reported methods.
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