期刊
CLINICAL AND TRANSLATIONAL ALLERGY
卷 11, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/clt2.12001
关键词
asthma; biomarkers; eosinophilic asthma; inflammation; neutrophilic asthma; phenotype
类别
资金
- Sanofi [02/055]
- Fondo de Investigacion Sanitaria-FIS [PI15/00803, PI15/01900]
- Merck Health Foundation
- CIBER de Enfermedades Respiratorias (CIBERES)
- Carlos III Institute of Health initiative
- FEDER funds
The MEGA project recruited 512 asthma patients, showing that severe asthmatic patients had more symptoms, exacerbations, lower asthma control, increased airflow obstruction, and higher frequency of chronic rhinosinusitis with nasal polyps, severe rhinitis, anxiety and depression, gastroesophageal reflux, and bronchiectasis compared to patients with milder disease.
Introduction The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma and multimorbidities in order to gain insight into the different physiopathological mechanisms involved in this disorder. Material and Methods We report the baseline clinical and physiological characteristics and biomarker measures of adult participants in the project with the aim of better understanding the natural history and underlying mechanisms of asthma as well as the associated multimorbidities across different levels of severity. We carried out a detailed clinical examination, pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), blood counts, induced sputum, skin prick tests, chest computed tomography scan, asthma questionnaires, and multimorbidity assessment in 512 asthmatic patients. Results When compared to patients with milder disease, severe asthmatic patients showed greater presence of symptoms, more exacerbations, lower asthma control, increased airflow obstruction, and higher frequency of chronic rhinosinusitis with nasal polyps, severe rhinitis, anxiety and depression, gastroesophageal reflux, and bronchiectasis. Conclusion The MEGA project succeeded in recruiting a high number of asthma patients, especially those with severe disease, who showed lower control and higher frequency of multimorbidities.
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