4.6 Article

Visuomotor Activation of Inhibition-Processing in Pediatric Obsessive Compulsive Disorder: A Magnetoencephalography Study

期刊

FRONTIERS IN PSYCHIATRY
卷 12, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2021.632736

关键词

primary motor cortex; anterior cingulate cortex; orbitofrontal cortex; response-inhibition; magnetoencephalography; pediatric; obsessive compulsive disorder; precuneus

资金

  1. Ontario Mental Health Foundation (OMHF) New Investigator Fellowship
  2. National Institute of Mental Health [R01MH114879]
  3. Canadian Institutes of Health Research [CIHR-IRSC: 0093005620]
  4. Department of Psychiatry, University of Toronto
  5. Autism Speaks
  6. CAMH Foundation
  7. Alberta Innovates Translational Health Chair in Child and Youth Mental Health
  8. Brain Canada
  9. Stem Cell Network
  10. Ontario Institute for Regenerative Medicine
  11. Garron Family Cancer Centre
  12. Natural Sciences and Engineering Research Council of Canada
  13. Scottish Rite Foundation

向作者/读者索取更多资源

Our study found no differences in response inhibition performance between medication-naive youth with OCD and typical developing controls. However, we observed significantly increased activity in the primary motor cortex (MI) during the Go condition and reduced activity in the precuneus (PCu) following successful stopping to No-Go cues in the OCD group compared to TDC, suggesting differences in neural response outside of the CSTC region. Further imaging research is needed to clarify regional differences associated with OCD and the influence of medication effects, with MEG showing promise in detecting such differences.
Background: Response inhibition engages the cortico-striato-thalamo-cortical (CSTC) circuit, which has been implicated in children, and youth with obsessive compulsive disorder (OCD). This study explored whether CSTC engagement during response inhibition, measured using magnetoencephalography (MEG), differed in a sample of medication-naive youth with OCD, compared to typically developing controls (TDC). Methods: Data was analyzed in 17 medication-naive children and youth with OCD (11.7 +/- 2.2 SD years) and 13 TDC (12.6 +/- 2.2 SD years). MEG was used to localize and characterize neural activity during a Go/No-Go task. Task performance on Go/No-Go conditions and regional differences in amplitude of activity during Go and No-Go condition between OCD vs. TDC were examined using two-sample t-tests. Post-hoc analysis with Bayesian t-tests was used to estimate the certainty of outcomes. Results: No differences in Go/No-Go performance were found between OCD and TDC groups. In response to the visual cue presented during the Go condition, participants with OCD showed significantly increased amplitude of activity in the primary motor (MI) cortex compared to TDC. In addition, significantly reduced amplitude of PCu was found following successful stopping to No-Go cues in OCD vs. TDC during No-Go task performance. Bayesian t-tests indicated high probability and large effect sizes for the differences in MI and PCu amplitude found between groups. Conclusion: Our preliminary study in a small medication-naive sample extends previous work indicating intact response inhibition in pediatric OCD. While altered neural response in the current study was found during response inhibition performance in OCD, differences localized to regions outside of the CSTC. Our findings suggest that additional imaging research in medication-naive samples is needed to clarify regional differences associated with OCD vs. influenced by medication effects, and suggest that MEG may be sensitive to detecting such differences.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据