期刊
FRONTIERS IN ENDOCRINOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.632457
关键词
diabetic retinopathy; electroretinogram; diagnostic model; risk factor; decision tree
资金
- Natural Science Foundation of Guangdong Province [2015A030313019]
- Sun Yat-sen Clinical Research Cultivation Project
The study constructed a proper model for screening diabetic retinopathy (DR) using RETeval. By combining the DR risk assessment protocol with the decision tree model, it improved the sensitivity of diagnosing DR, making it more suitable for DR screening than the current protocol.
Purpose: To construct a proper model to screen for diabetic retinopathy (DR) with the RETeval. Method: This was a cross-sectional study. Two hundred thirty-two diabetic patients and seventy controls were recruited. The DR risk assessment protocol was performed to obtain subjects' DR risk score using the RETeval. Afterwards, the receiver operating characteristic (ROC) curve was used to determine the best cutoff for diagnosing DR. Random forest and decision tree models were constructed. Results: With increasing DR severity, the DR score gradually increased. When the DR score was used to diagnose DR, the ROC curve had an area under the curve of 0.881 (95% confidence interval: 0.836-0.927, P < 0.001), with a best cutoff value of 22.95, a sensitivity of 74.3% (95 CI: 66.0%similar to 82.6%), and a specificity of 90.6% (95 CI: 83.7%similar to 94.8%). The top four risk factors selected by the random forest were used to construct the decision tree for diagnosing DR, which had a sensitivity of 93.3% (95% CI: 86.3%similar to 97.0%) and a specificity of 80.3% (95% CI: 72.1%similar to 86.6%). Conclusions: The DR risk assessment protocol combined with the decision tree model was innovatively used to evaluate the risk of DR, improving the sensitivity of diagnosis, which makes this method more suitable than the current protocol for DR screening.
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