期刊
FRONTIERS IN ENDOCRINOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.653972
关键词
MondoA; ChREBP; nutrient-sensing; obesity; brown and beige adipose tissue
资金
- 14th Undergraduate Training Programfor Innovation of Shanghai Jiao TongUniversity School of Medicine [1420Y002]
- National Natural Science Foundation of China [81672322, 81972210, 92057117]
- Shanghai Municipal Science and Technology Major Project [19JC1410200]
- National Key R&D Program of China [2019YFA0906100]
- National Key Research and Development Program of China [2016YFC1304800]
- Shanghai Jiao Tong University School of Medicine and Innovative research team of high-level local universities in Shanghai [SSMU-ZDCX20180400]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and Construction
- Plan of Laboratory Technical Team in Shanghai Universities [SYjdyx19019]
This review provides an overview of the recent advances in understanding the role of Mondo family transcription factors in sensing nutrients and regulating obesity, as well as their involvement in obesity and related pathological conditions.
In the past several decades obesity has become one of the greatest health burdens worldwide. Diet high in fats and fructose is one of the main causes for the prevalence of metabolic disorders including obesity. Promoting brown or beige adipocyte development and activity is regarded as a potential treatment of obesity. Mondo family transcription factors including MondoA and carbohydrate response element binding protein (ChREBP) are critical for nutrient-sensing in multiple metabolic organs including the skeletal muscle, liver, adipose tissue and pancreas. Under normal nutrient conditions, MondoA and ChREBP contribute to maintaining metabolic homeostasis. When nutrient is overloaded, Mondo family transcription factors directly regulate glucose and lipid metabolism in brown and beige adipocytes or modulate the crosstalk between metabolic organs. In this review, we aim to provide an overview of recent advances in the understanding of MondoA and ChREBP in sensing nutrients and regulating obesity or related pathological conditions.
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