期刊
REDOX BIOLOGY
卷 41, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.redox.2021.101933
关键词
Oral microbiome; Nitric oxide; Aging
资金
- Dunhill Medical Trust [R269/1112]
- Wellcome Trust's Institutional Strategic Support Fund
- NIHR [CRF/2016/10027]
- Medical Research Council Clinical Infrastructure award [MR/M008924/1]
- Wellcome Trust Institutional Strategic Support Fund [WT097835MF]
- Wellcome Trust Multi User Equipment Award [WT101650MA]
- BBSRC LOLA award [BB/K003240/1]
- National Institutes of Health Research (NIHR) [CRF-2016-10027] Funding Source: National Institutes of Health Research (NIHR)
The study found that after nitrate supplementation, there were changes in the relative abundance of oral bacteria, which had stable effects on cardiovascular health and cognitive function. The nitrate-sensitive oral microbiome modules may serve as potential targets for improving cardiovascular and cognitive health in older people.
Many oral bacteria reduce inorganic nitrate, a natural part of a vegetable-rich diet, into nitrite that acts as a precursor to nitric oxide, a regulator of vascular tone and neurotransmission. Aging is hallmarked by reduced nitric oxide production with associated detriments to cardiovascular and cognitive function. This study applied a systems-level bacterial co-occurrence network analysis across 10-day dietary nitrate and placebo interventions to test the stability of relationships between physiological and cognitive traits and clusters of co-occurring oral bacteria in older people. Relative abundances of Proteobacteria increased, while Bacteroidetes, Firmicutes and Fusobacteria decreased after nitrate supplementation. Two distinct microbiome modules of co-occurring bacteria, that were sensitive to nitrate supplementation, showed stable relationships with cardiovascular (RothiaStreptococcus) and cognitive (Neisseria-Haemophilus) indices of health across both dietary conditions. A microbiome module (Prevotella-Veillonella) that has been associated with pro-inflammatory metabolism was diminished after nitrate supplementation, including a decrease in relative abundance of pathogenic Clostridium difficile. These nitrate-sensitive oral microbiome modules are proposed as potential pre- and probiotic targets to ameliorate age-induced impairments in cardiovascular and cognitive health.
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