Mechanisms of Candida Resistance to Antimycotics and Promising Ways to Overcome It: The Role of Probiotics

Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.

Automated summary

Pathogenic Candida and infections caused by those species are considered a serious threat to public health. Treatment of candidiasis is complicated by increasing resistance to current treatments and lack of development of new antimycotic drugs. Among synthetic antifungal drugs, azoles and echinocandins are effective, while the use of probiotic microorganisms to control the spread of pathogenic Candida species shows promise.