相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Metformin and Risk of Alzheimer's Disease Among Community-Dwelling People With Diabetes: A National Case-Control Study
Janet K. Sluggett et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)
Differential regulation of autophagy during metabolic stress in astrocytes and neurons
Aditi Kulkarni et al.
AUTOPHAGY (2020)
Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action
Mareike Schell et al.
NUTRIENTS (2020)
Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia A Randomized Clinical Trial
Suzanne Craft et al.
JAMA NEUROLOGY (2020)
Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial
Tali Cukierman-Yaffe et al.
LANCET NEUROLOGY (2020)
Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function
Chantal Chudobaa et al.
BIOLOGICAL CHEMISTRY (2019)
Insulin Resistance and Oxidative Stress in the Brain: What's New?
Mateusz Maciejczyk et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior
Marion Soto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Rosiglitazone has a neutral effect on the risk of dementia in type 2 diabetes patients
Chin-Hsiao Tseng
AGING-US (2019)
Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression
Julia A. Hamer et al.
EXPERIMENTAL NEUROLOGY (2019)
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease
Tomoko Wakabayashi et al.
MOLECULAR NEURODEGENERATION (2019)
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
Caroline Fecher et al.
NATURE NEUROSCIENCE (2019)
Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance
Elizabeth M. Rhea et al.
FRONTIERS IN NEUROSCIENCE (2019)
Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case control study
Ida Kim Wium-Andersen et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)
Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain
Kristina Wardelmann et al.
MOLECULAR METABOLISM (2019)
Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain
Gregory N. Ruegsegger et al.
JCI INSIGHT (2019)
Insulin transport into the brain
Sarah M. Gray et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)
TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding
Garron T. Dodd et al.
DIABETES (2018)
Insulin regulates astrocyte gliotransmission and modulates behavior
Weikang Cai et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels
J. Qiu et al.
JOURNAL OF NEUROENDOCRINOLOGY (2018)
Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes
Sreemathi Logan et al.
MOLECULAR METABOLISM (2018)
13 reasons why the brain is susceptible to oxidative stress
James Nathan Cobley et al.
REDOX BIOLOGY (2018)
Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis
Jared M. Campbell et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
Altered mitochondrial function in insulin-deficient and insulin-resistant states
Gregory N. Ruegsegger et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance
Mateusz Maciejczyk et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Insulin regulates POMC neuronal plasticity to control glucose metabolism
Garron T. Dodd et al.
ELIFE (2018)
Links Between Obesity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia
Jirapas Sripetchwandee et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function
Jordan Rowlands et al.
FRONTIERS IN ENDOCRINOLOGY (2018)
Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation
Candace M. Reno et al.
DIABETES (2017)
Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I
Ana M. Fernandez et al.
DIABETES (2017)
Insulin Receptor Isoforms in Physiology and Disease: An Updated View
Antonino Belfiore et al.
ENDOCRINE REVIEWS (2017)
Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice
Farhana Naznin et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2017)
Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial
Suzanne Craft et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Insulin action in the brain: Roles in energy and glucose homeostasis
G. T. Dodd et al.
JOURNAL OF NEUROENDOCRINOLOGY (2017)
A molecular census of arcuate hypothalamus and median eminence cell types
John N. Campbell et al.
NATURE NEUROSCIENCE (2017)
SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats
Piangkwan Sa-nguanmoo et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)
Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms
Jesse S. Kerr et al.
TRENDS IN NEUROSCIENCES (2017)
Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action
Beatrice M. Filippi et al.
CELL REPORTS (2017)
Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation
J. D. Douglass et al.
MOLECULAR METABOLISM (2017)
Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity
Yuanqing Gao et al.
DIABETES (2017)
A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding (vol 26, pg 375, 2017)
Garron T. Dodd et al.
CELL METABOLISM (2017)
The mechanisms of action of metformin
Graham Rena et al.
DIABETOLOGIA (2017)
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control
Sara Ramirez et al.
CELL METABOLISM (2017)
Insulin Receptor Signaling in POMC, but Not AgRP, Neurons Controls Adipose Tissue Insulin Action
Andrew C. Shin et al.
DIABETES (2017)
Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight
Yalin Zhang et al.
CELL METABOLISM (2017)
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
Anna Santoro et al.
CELL METABOLISM (2017)
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton et al.
CELL (2017)
High fat diet induces brain insulin resistance and cognitive impairment in mice
Vishal Kothari et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia
Saion Chatterjee et al.
DIABETES CARE (2016)
Pathways for insulin access to the brain: the role of the microvascular endothelial cell
Rick I. Meijer et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)
Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus
Chrysi Koliaki et al.
ANNUAL REVIEW OF NUTRITION, VOL 36 (2016)
Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
Cristina Garcia-Caceres et al.
CELL (2016)
Bioenergetics and redox adaptations of astrocytes to neuronal activity
Juan P. Bolanos
JOURNAL OF NEUROCHEMISTRY (2016)
Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling
A. Kleinridders
JOURNAL OF NEUROENDOCRINOLOGY (2016)
Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity
Claudia A. Grillo et al.
DIABETES (2015)
Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance
Geraldine Gontier et al.
JOURNAL OF NEUROSCIENCE (2015)
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Tiia Ngandu et al.
LANCET (2015)
Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease
Giuseppe Verdile et al.
MEDIATORS OF INFLAMMATION (2015)
Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans
Ellen A. Schur et al.
OBESITY (2015)
Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation
Maja Jazvinscak Jembrek et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Andre Kleinridders et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Hypothalamic inflammation and gliosis in obesity
Mauricio D. Dorfman et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2015)
Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin
Rita Slaaby
SCIENTIFIC REPORTS (2015)
Innate Immune Response in Brain, NF-Kappa B Signaling and Cystatins
Natasa Kopitar-Jerata
FRONTIERS IN MOLECULAR NEUROSCIENCE (2015)
Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model
Shengbin Huang et al.
DIABETES (2015)
Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia
Amy Claxton et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Evidence for altered transport of insulin across the blood-brain barrier in insulin-resistant humans
Martin Heni et al.
ACTA DIABETOLOGICA (2014)
Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels
Jian Qiu et al.
CELL METABOLISM (2014)
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
Andre Kleinridders et al.
DIABETES (2014)
Mitochondrial form and function
Jonathan R. Friedman et al.
NATURE (2014)
Sirt1 Rescues the Obesity Induced by Insulin-Resistant Constitutively-Nuclear FoxO1 in POMC Neurons of Male Mice
Vina Yanti Susanti et al.
OBESITY (2014)
Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα
Eugenia Morselli et al.
CELL REPORTS (2014)
Role of Nrf2 in Oxidative Stress and Toxicity
Qiang Ma
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)
Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity
Marcelo O. Dietrich et al.
CELL (2013)
Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance
Marc Schneeberger et al.
CELL (2013)
Lipid signals and insulin resistance
Chongben Zhang et al.
CLINICAL LIPIDOLOGY (2013)
AgRP Innervation onto POMC Neurons Increases with Age and Is Accelerated with Chronic High-Fat Feeding in Male Mice
A. Jamila Newton et al.
ENDOCRINOLOGY (2013)
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling
Andre Kleinridders et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Hypothalamic malonyl-CoA and the control of food intake
Su Gao et al.
PHYSIOLOGY & BEHAVIOR (2013)
Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion
Stephane G. Rolland et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment A Pilot Clinical Trial
Suzanne Craft et al.
ARCHIVES OF NEUROLOGY (2012)
Bioenergetic role of mitochondrial fusion and fission
Benedikt Westermann
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2012)
Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production
Beatrice M. Filippi et al.
CELL METABOLISM (2012)
Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease
Suzanne M. de la Monte
Current Alzheimer Research (2012)
Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans
Kamila Jauch-Chara et al.
DIABETES (2012)
Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women
Manfred Hallschmid et al.
DIABETES (2012)
Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
Luis Varela et al.
EMBO REPORTS (2012)
PPAR gamma Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets
Noppamas Pipatpiboon et al.
ENDOCRINOLOGY (2012)
Mitochondrial redox signalling at a glance (vol 125, pg 801, 2012)
Yvonne Collins et al.
JOURNAL OF CELL SCIENCE (2012)
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Konrad Talbot et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study
Patrick Imfeld et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2012)
Mitochondria, oxidative stress and neurodegeneration
Antonio Federico et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)
Physiological Roles of Mitochondrial Reactive Oxygen Species
Laura A. Sena et al.
MOLECULAR CELL (2012)
Regulation of glucose transport by insulin: traffic control of GLUT4
Dara Leto et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Mechanism of Oxidative Stress in Neurodegeneration
Sonia Gandhi et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)
Effect of Insulin Analogues on Insulin/IGF1 Hybrid Receptors: Increased Activation by Glargine but Not by Its Metabolites M1 and M2
Cecile Pierre-Eugene et al.
PLOS ONE (2012)
Associations of Fatty Acids in Cerebrospinal Fluid with Peripheral Glucose Concentrations and Energy Metabolism
Reiner Jumpertz et al.
PLOS ONE (2012)
Crosstalk of reactive oxygen species and NF-kappa B signaling
Michael J. Morgan et al.
CELL RESEARCH (2011)
Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men
Christian Benedict et al.
DIABETES (2011)
Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors
Manuel Sanchez-Alavez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
Ying Liu et al.
JOURNAL OF PATHOLOGY (2011)
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Berislav V. Zlokovic
NATURE REVIEWS NEUROSCIENCE (2011)
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
Roberto Zoncu et al.
SCIENCE (2011)
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
Kristy Iskandar et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism
Ryo Suzuki et al.
CELL METABOLISM (2010)
Increased Brain Fatty Acid Uptake in Metabolic Syndrome
Anna Karmi et al.
DIABETES (2010)
Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
Kelly A. Diggs-Andrews et al.
DIABETES (2010)
Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
L. Sciacca et al.
DIABETOLOGIA (2010)
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
Carl Julien et al.
NEUROBIOLOGY OF AGING (2010)
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
Tamas L. Horvath et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Insulin signaling meets mitochondria in metabolism
Zhiyong Cheng et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)
Selective neuronal vulnerability to oxidative stress in the brain
Xinkun Wang et al.
FRONTIERS IN AGING NEUROSCIENCE (2010)
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial
Jolien de Jager et al.
BMJ-BRITISH MEDICAL JOURNAL (2010)
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
Kelly A. Posey et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
CNS-targets in control of energy and glucose homeostasis
Andre Kleinridders et al.
CURRENT OPINION IN PHARMACOLOGY (2009)
Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease
Antonino Belfiore et al.
ENDOCRINE REVIEWS (2009)
Hepatic Ceramide May Mediate Brain Insulin Resistance and Neurodegeneration in Type 2 Diabetes and Non-alcoholic Steatohepatitis
Lascelles E. Lyn-Cook et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Mechanisms of Ceramide-Mediated Neurodegeneration
Ming Tong et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation
Silvia Mangia et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats (Publication with Expression of Concern. See vol. 594, pg. 5025, 2016) (Publication with Expression of Concern. See vol. 594, pg. 5025, 2016) (Publication with Expression of Concern. See vol. 594, pg. 5025, 2016)
Eduardo R. Ropelle et al.
JOURNAL OF PHYSIOLOGY-LONDON (2009)
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
Leona Plum et al.
NATURE MEDICINE (2009)
Foxo1 integrates insulin signaling with mitochondrial function in the liver
Zhiyong Cheng et al.
NATURE MEDICINE (2009)
Insulin rescues amyloid β-induced impairment of hippocampal long-term potentiation
Cheng-Che Lee et al.
NEUROBIOLOGY OF AGING (2009)
Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
Fernanda G. De Felice et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Central insulin action regulates peripheral glucose and fat metabolism in mice
Linda Koch et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
Jennifer W. Hill et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
The blood-brain barrier in health and chronic neurodegenerative disorders
Berislav V. Zlokovic
NEURON (2008)
Intranasal insulin improves cognition and modulates β-amyloid in early AD
M. A. Reger et al.
NEUROLOGY (2008)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Ian A. Simpson et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
A. Christine Koenner et al.
CELL METABOLISM (2007)
Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation
Samira Benyoucef et al.
BIOCHEMICAL JOURNAL (2007)
Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: A shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
Pavel Katsel et al.
NEUROCHEMICAL RESEARCH (2007)
Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance - The cerebral basis for impaired control of food intake in metabolic syndrome?
Karen Anthony et al.
DIABETES (2006)
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
Stefan M. Schieke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
Rita Slaaby et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity
Jeff R. Liddell et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans:: A magnetoencephalographic study
Otto Tschritter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Leona Plum et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
Min-Seon Kim et al.
NATURE NEUROSCIENCE (2006)
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
Tadahiro Kitamura et al.
NATURE MEDICINE (2006)
Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3
E Uemura et al.
EXPERIMENTAL NEUROLOGY (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis
E. Carro et al.
NEUROBIOLOGY OF AGING (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Risk of dementia in diabetes mellitus: a systematic review
GJ Biessels et al.
LANCET NEUROLOGY (2006)
Growing roles for the mTOR pathway
DD Sarbassov et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-D-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner
LP van der Heide et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia
SJ Fisher et al.
DIABETES (2005)
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes?
E Steen et al.
JOURNAL OF ALZHEIMERS DISEASE (2005)
Role for neuronal insulin resistance in neurodegenerative diseases
M Schubert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
L Ho et al.
FASEB JOURNAL (2004)
Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease
AV Alessenko et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
Intranasal insulin improves memory in humans
C Benedict et al.
PSYCHONEUROENDOCRINOLOGY (2004)
Intranasal insulin reduces body fat in men but not in women
M Hallschmid et al.
DIABETES (2004)
Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
G Pandini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Caloric intake and the risk of Alzheimer disease
JA Luchsinger et al.
ARCHIVES OF NEUROLOGY (2002)
Different responses of astrocytes and neurons to nitric oxide:: The role of glycolytically generated ATP in astrocyte protection
A Almeida et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling
L Gasparini et al.
JOURNAL OF NEUROSCIENCE (2001)
Role for mitochondrial oxidants as regulators of cellular metabolism
S Nemoto et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
D Spanswick et al.
NATURE NEUROSCIENCE (2000)
Role of oxidants in NF-κB activation and TNF-α gene transcription induced by hypoxia and endotoxin
NS Chandel et al.
JOURNAL OF IMMUNOLOGY (2000)
分享论文
