4.3 Review

EFFECT OF LOCALLY DELIVERED BISPHOSPHONATES ON ALVEOLAR BONE: A SYSTEMATIC REVIEW AND META-ANALYSIS

期刊

出版社

ELSEVIER INC
DOI: 10.1016/j.jebdp.2021.101580

关键词

Alveolar bone; Bisphosphonates; Bone loss; Bone regeneration

向作者/读者索取更多资源

Locally delivered bisphosphonates have a positive effect on alveolar bone regeneration in patients with periodontitis and can reduce marginal bone loss after dental implant placement.
Objective To assess the effect of locally applied bisphosphonate drugs on alveolar bone defects caused by periodontitis and marginal bone level after placement of dental implants. Materials and Methods Three electronic databases (PubMed/MEDLINE, Web of Science, and Scopus) were searched from January 2010 until May 2020 for randomized controlled clinical trials reporting the effect of locally delivered bisphosphonates on alveolar bone. The risk of bias was assessed and quantitative synthesis was conducted with both fixed and random-effects meta-analyses by using RevMan version 5.3. Subgroup and sensitivity analyses were performed whenever required. Results Among the included studies, the effect of locally delivered bisphosphonates on alveolar bone regeneration in periodontitis was measured by 15 studies and on marginal bone level after installation of dental implants by three studies. Bisphosphonates showed significantly higher intrabony defect depth reduction than placebo/control in vertical bone defects treated with non-surgical approach (MD =1.69mm; 95% CI, 1.32-2.05; P < 0.00001; I-2= 93%) or surgical approach (MD =0.70mm; 95% CI, 0.23-1.16; P = 0.003; I 2 = 78%) and in class II furcation defects treated with non-surgical approach (MD =1.61mm; 95% CI, 1.15-2.07; P < 0.00001; I-2 = 99%) or surgical approach (MD =0.24mm; 95% CI, 0.05-0.42; P = 0.01; I-2 = 62%). Clinical attachment loss increased by 1.39mm (95% CI, 0.921.85; P < 0.01; I-2= 93%) and 1mm (95% CI, 0.75-1.26; P < 0.001; I-2 = 0%) in vertical bone defects after non-surgical and surgical treatments, respectively, and by 1.95mm (95% CI, 1.37-2.53; P < 0.00001; I-2 = 96%) and 0.84mm (95% CI, 0.58-1.10; P < 0.01, I-2 = 47%) after non-surgical and surgical treatment in class II furcation defects, respectively. Lesser marginal bone loss during pre-loading (MD = -0.18 mm; 95% CI, -0.24-0.12;P < 0.00001; I-2= 0%) and 1-year post-loading (MD = -0.33 mm; 95% CI,-0.59-0.07; P = 0.01; I-2 = 0%) periods was observed when bisphosphonate coated dental implants were used. Conclusion Locally delivered bisphosphonates induce bone regeneration in periodontal defects and decrease the rate of marginal bone loss after dental implant therapy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据