期刊
INFLAMMOPHARMACOLOGY
卷 29, 期 4, 页码 907-923出版社
SPRINGER BASEL AG
DOI: 10.1007/s10787-021-00799-7
关键词
Cyanidin-3-glucoside; Oxidative stress; Nrf2 pathway; ROS; Antioxidant
资金
- American University of Ras Al Khaimah (AURAK)
C3G, a natural antioxidant found in berries, exerts its cytoprotective effects in vivo by modulating the Nrf2 pathway, helping to combat oxidative stress-induced DNA damage, apoptosis, carcinogen toxicity, and inflammatory conditions.
Berries are natural sources of anthocyanins, especially cyanidin-3-glucoside (C3G), and exhibit significant antioxidant, antidiabetic, anti-inflammatory, and cytoprotective effects against various oxidative stress-induced disorders. C3G and its metabolites possess higher absorption and bioavailability, and interaction with gut microbiota may enhance their health benefits. Various in vitro studies have shown the reactive oxygen species (ROS)-mitigating potential of C3G. However, in in vivo models, C3G exerts its cytoprotective properties by regulating the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant-responsive element (ARE) pathway. Despite existing reports stating various health benefits of C3G, its antioxidant potential by modulating the Nrf2 pathway remains less identified. This review discusses the Nrf2-mediated antioxidant response of C3G in modulating oxidative stress against DNA damage, apoptosis, carcinogen toxicity, and inflammatory conditions. Furthermore, we have reviewed the recent clinical trial data to establish cross talk between a berry-rich diet and disease prevention.
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