期刊
FRONTIERS IN NEUROLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2021.620757
关键词
mild traumatic brain injury; cerebral blood flow; blood pressure; baroreflex; autonomic function
资金
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR001412]
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [1R01NS094444]
Athletes with concussions show impaired tolerance to lower body negative pressure and have a different cerebral vascular response to lower body positive pressure compared to healthy controls.
Concussions have been shown to result in autonomic dysfunction and altered cerebral vascular function. We tested the hypothesis that concussed athletes (CA) would have altered cerebral vascular function during acute decreases and increases in blood pressure compared to healthy controls (HC). Ten CA (age: 20 +/- 2 y, 7 females) and 10 HC (age: 21 +/- 2 y, 6 females) completed 5 min of lower body negative pressure (LBNP; -40 mmHg) and 5 min of lower body positive pressure (LBPP; 20 mmHg). Protocols were randomized and separated by 10 min. Mean arterial pressure (MAP) and middle cerebral artery blood velocity (MCAv) were continuously recorded. Cerebral vascular resistance (CVR) was calculated as MAP/MCAv. Values are reported as change from baseline to the last minute achieved (LBNP) or 5 min (LBPP). There were no differences in baseline values between groups. During LBNP, there were no differences in the change for MAP (CA: -23 +/- 18 vs. HC: -21 +/- 17 cm/s; P = 0.80) or MCAv (CA: -13 +/- 8 vs. HC: -18 +/- 9 cm/s; P = 0.19). The change in CVR was different between groups (CA: -0.08 +/- 0.26 vs. HC: 0.18 +/- 0.24 mmHg/cm/s; P = 0.04). Total LBNP time was lower for CA (204 +/- 92 s) vs. HC (297 +/- 64 s; P = 0.04). During LBPP, the change in MAP was not different between groups (CA: 13 +/- 6 vs. HC: 10 +/- 7 mmHg; P = 0.32). The change in MCAv (CA: 7 +/- 6 vs. HC: -4 +/- 13 cm/s; P = 0.04) and CVR (CA: -0.06 +/- 0.27 vs. HC: 0.38 +/- 0.41 mmHg/cm/s; P = 0.03) were different between groups. CA exhibited impaired tolerance to LBNP and had a different cerebral vascular response to LBPP compared to HC.
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