期刊
FRONTIERS OF MEDICINE
卷 15, 期 2, 页码 264-274出版社
SPRINGER
DOI: 10.1007/s11684-021-0845-6
关键词
cancer; COVID-19; SARS-CoV-2; risk factor; mortality
资金
- State Key Project on Infectious Diseases of China [2018ZX10723204-003]
- National Natural Science Foundation of China [81874065, 81874149]
- Hepato-Biliary-Pancreatic Cancer Investigation Fund of Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province [CXPJJH11800001-2018356]
Cancer patients have a higher risk of COVID-19 infection and poorer prognosis compared to non-cancer patients. High-risk tumor, NRS2002 score > 3, advanced tumor stage, and recent adjuvant therapy (< 1 month) may be independent risk factors for in-hospital death among cancer patients.
Patients with cancer are at increased risk of severe infections. From a cohort including 3060 patients with confirmed COVID-19, 109 (3.4%) cancer patients were included in this study. Among them, 23 (21.1%) patients died in the hospital. Cancer patients, especially those with hematological malignancies (41.6%), urinary carcinoma (35.7%), malignancies of the digestive system (33.3%), gynecological malignancies (20%), and lung cancer (14.3%), had a much higher mortality than patients without cancer. A total of 19 (17.4%) cancer patients were infected in the hospital. The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients. Multivariate Cox regression analysis indicated that a Nutritional Risk Screening (NRS2002) score > 3 (adjusted hazard ratio (HR) 11.00; 95% confidence interval (CI) 4.60-26.32; P < 0.001), high-risk type (adjusted HR 18.81; 95% CI 4.21-83.93; P < 0.001), tumor stage IV (adjusted HR 4.26; 95% CI 2.34-7.75; P < 0.001), and recent adjuvant therapy (< 1 month) (adjusted HR 3.16; 95% CI 1.75-5.70; P < 0.01) were independent risk factors for in-hospital death after adjusting for age, comorbidities, D-dimer, and lymphocyte count. In conclusion, cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer. Cancer patients with high-risk tumor, NRS2002 score > 3, advanced tumor stage, and recent adjuvant therapy (< 1 month) may have high risk of mortality.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据