期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.605857
关键词
acute myocardial infarction; CX3CR1; cytomegalovirus; cardiac MRI; remodeling; T-lymphocytes
类别
资金
- ERA-NET
- Austrian Science Fund (FWF) [I 4168-B]
- Interdisciplinary Center for Clinical Research Wurzburg
- ERA-NET-CVD [01KL1902]
- German Research Foundation (DFG) [411619907]
- British Heart Foundation [PG/18/25/33587]
- National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre
- Newcastle University
- British Heart Foundation [PG/18/25/33587] Funding Source: researchfish
Latent CMV infection is associated with poor cardiovascular outcomes, with CMV+ patients showing more adverse LV remodeling possibly due to loss of CX(3)CR1(+) T-cells.
Aims Latent cytomegalovirus (CMV) infection is associated with adverse cardiovascular outcomes. Virus-specific CX(3)CR1(+) effector memory T-cells may be instrumental in this process due to their pro-inflammatory properties. We investigated the role of CX(3)CR1 (fractalkine receptor) in CMV-related lymphocyte kinetics and cardiac remodeling in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). Methods and Results We retrospectively analysed lymphocyte count, troponin, and survival in 4874 STEMI/pPCI patients, evaluated lymphocyte kinetics during reperfusion in a prospective cohort, and obtained sequential cardiac MRI (cMRI) to assess remodeling. Pre-reperfusion lymphopenia independently predicted mortality at 7.5 years. Prior to reperfusion, CCR7(+) T-lymphocytes appeared to be depleted. After reperfusion, T-lymphocytes expressing CX(3)CR1 were depleted predominantly in CMV-seropositive patients. During ischaemia/reperfusion, a drop in CX(3)CR1(+) T-lymphocytes was significantly linked with microvascular obstruction in CMV+ patients, suggesting increased fractalkine-receptor interaction. At 12 weeks, CMV+ patients displayed adverse LV remodeling. Conclusion We show that lymphopenia occurs before and after reperfusion in STEMI by different mechanisms and predicts long-term outcome. In CMV+ patients, increased fractalkine induction and sequestration of CX(3)CR1(+) T-cells may contribute to adverse remodeling, suggesting a pro-inflammatory pathomechanism which presents a novel therapeutic target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据