期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.682871
关键词
M1; M2 macrophages; inflammation; ARDS; cells therapy; SARS-CoV-2
类别
资金
- Russian Foundation for Basic Research [20-04-60027]
- RUDN University Strategic Academic Leadership Program
Macrophages play a crucial role in COVID-19, especially in cases complicated by ARDS. Macrophage activation syndrome is predominantly caused by massive activation of macrophages. Reprogrammed macrophages with stable pro- or anti-inflammatory phenotypes may have potential utility in the treatment of ARDS.
Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a major role in both physiological and pathological processes. Systemic SARS-CoV-2-associated complications include acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation syndrome, edema, and pneumonia. These are predominantly effects of massive macrophage activation that collectively can be defined as macrophage activation syndrome. In this review we focus on the role of macrophages in COVID-19, as pathogenesis of the new coronavirus infection, especially in cases complicated by ARDS, largely depends on macrophage phenotypes and functionalities. We describe participation of monocytes, monocyte-derived and resident lung macrophages in SARS-CoV-2-associated ARDS and discuss possible utility of cell therapies for its treatment, notably the use of reprogrammed macrophages with stable pro- or anti-inflammatory phenotypes.
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