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Immunometabolism of Tissue-Resident Macrophages - An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies

期刊

FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.665782

关键词

tissue-resident macrophages; metabolism; homeostasis; inflammation; development

资金

  1. NIH NCI [5R00CA237728-03, 1R01CA248364-01A1]
  2. Parker Institute for Cancer Immunotherapy Career Development Award (Perry laboratory)
  3. MSKCC Cancer Center Support Grant [P30CA008748]

向作者/读者索取更多资源

The metabolic state of tissue-resident macrophages directly influences their function, studying metabolic requirements is crucial for understanding their identity, response to inflammatory challenges, and execution of homeostatic functions. Emerging technologies are driving in situ study of tissue-resident macrophage metabolism.
Tissue-resident macrophages exist in unique environments, or niches, that inform their identity and function. There is an emerging body of literature suggesting that the qualities of this environment, such as the types of cells and debris they eat, the intercellular interactions they form, and the length of time spent in residence, collectively what we call habitare, directly inform their metabolic state. In turn, a tissue-resident macrophage's metabolic state can inform their function, including whether they resolve inflammation and protect the host from excessive perturbations of homeostasis. In this review, we summarize recent work that seeks to understand the metabolic requirements for tissue-resident macrophage identity and maintenance, for how they respond to inflammatory challenges, and for how they perform homeostatic functions or resolve inflammatory insults. We end with a discussion of the emerging technologies that are enabling, or will enable, in situ study of tissue-resident macrophage metabolism.

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