期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.654731
关键词
innate immune cells; crosstalk; regulation; esophageal tumor microenvironment; immunotherapy strategy
类别
资金
- Natural Science Foundation of Anhui Province [2008085MH277]
- National Natural Science Foundation of China [81471552]
- Anhui Provincial Project of the Key Laboratory of Tumor Immunotherapy and Nutrition Therapy [2019b12030026]
The review discusses recent progress in research on innate immune cells in the esophageal cancer microenvironment, highlighting potential directions for the development of new biomarkers and effective intervention targets. Understanding the innate immunological mechanisms involved in esophageal mucosa carcinogenesis is crucial for clinical immunotherapy and prognosis prediction for patients with EC.
Esophageal cancer (EC) is one of the most common mucosa-associated tumors, and is characterized by aggressiveness, poor prognosis, and unfavorable patient survival rates. As an organ directly exposed to the risk of foodborne infection, the esophageal mucosa harbors distinct populations of innate immune cells, which play vital roles in both maintenance of esophageal homeostasis and immune defense and surveillance during mucosal anti-infection and anti-tumor responses. In this review, we highlight recent progress in research into innate immune cells in the microenvironment of EC, including lymphatic lineages, such as natural killer and gamma delta T cells, and myeloid lineages, including macrophages, dendritic cells, neutrophils, myeloid-derived suppressor cells, mast cells and eosinophils. Further, putative innate immune cellular and molecular mechanisms involved in tumor occurrence and progression are discussed, to highlight potential directions for the development of new biomarkers and effective intervention targets, which can hopefully be applied in long-term multilevel clinical EC treatment. Fully understanding the innate immunological mechanisms involved in esophageal mucosa carcinogenesis is of great significance for clinical immunotherapy and prognosis prediction for patients with EC.
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