4.8 Review

Reactions Related to CAR-T Cell Therapy

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Article Hematology

Immune reconstitution and associated infections following axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma

Jennifer M. Logue et al.

Summary: A retrospective study of 85 patients receiving axi-cel for LBCL found that prolonged cytopenias and infections were common post-treatment, with most patients experiencing recovery of these conditions over time. Infections within the first 30 days were associated with various factors, but no late deaths were attributed to infection.

HAEMATOLOGICA (2021)

Article Hematology

Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma

Paolo Strati et al.

Summary: Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 can lead to long-term adverse effects such as cytopenia and immune deficiency. Prolonged monitoring and prophylaxis against opportunistic infections are crucial to improve the long-term safety of this therapy.

HAEMATOLOGICA (2021)

Review Oncology

Side-effect management of chimeric antigen receptor (CAR) T-cell therapy

M-L Schubert et al.

Summary: CAR T-cell therapy targeting CD19-expressing B cells has shown promising results in treating refractory and/or relapsed B-cell malignancies, but also presents challenges such as cytokine release syndrome and neurotoxicity syndrome. Optimal management strategies for the side-effects associated with CAR T-cell therapy are crucial as it expands into other diseases in hematology and oncology.

ANNALS OF ONCOLOGY (2021)

Review Hematology

Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies

Takayuki Ikezoe

Summary: Haematological malignancies can cause DIC, with concomitant poor prognosis. The Japanese Society on Thrombosis and Hemostasis has released new DIC diagnostic criteria and recombinant human soluble thrombomodulin is commonly used for treatment. Innovative therapies like HSCT and CAR-T-cell therapy can cure some patients with haematological malignancies, but may lead to coagulopathy.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

Article Hematology

Prolonged hematologic toxicity following treatment with chimeric antigen receptor T cells in patients with hematologic malignancies

Sarah J. Nagle et al.

Summary: CAR T-cell therapy is effective in treating patients with R/R DLBCL, but it is associated with significant prolonged hematologic toxicity (PHT) that can affect patients' survival rates. Risk factors associated with PHT include CRS, the use of tocilizumab or steroids, peak levels of ferritin and C-reactive protein. More research is needed to further investigate PHT and establish management standards.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Medicine, General & Internal

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

Nikhil C. Munshi et al.

Summary: The phase 2 study confirmed the efficacy and safety of ide-cel in patients with relapsed and refractory myeloma, with a majority of patients achieving responses and 26% achieving MRD-negative status. Despite the high response rate, almost all patients experienced grade 3 or 4 toxic effects, including hematologic toxic effects and cytokine release syndrome.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Hematology

Late Events after Treatment with CD19-Targeted Chimeric Antigen Receptor Modified T Cells

Ana Cordeiro et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2020)

Article Multidisciplinary Sciences

Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

Norris Lam et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, General & Internal

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

Michael Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Allergy

Cytokine release syndrome and neurotoxicity following CAR T-cell therapy for hematologic malignancies

Craig W. Freyer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Oncology

Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer

Hua Jiang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Article Oncology

Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer

Hua Jiang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Article Biophysics

Early and late hematologic toxicity following CD19 CAR-T cells

Shalev Fried et al.

BONE MARROW TRANSPLANTATION (2019)

Article Oncology

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer

Jiang Lv et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Hematology

Improving the safety of CAR-T cell therapy by controlling CRS-related coagulopathy

Huiwen Jiang et al.

ANNALS OF HEMATOLOGY (2019)

Article Biotechnology & Applied Microbiology

Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma

Xiuqi Wu et al.

MOLECULAR THERAPY (2019)

Article Medicine, General & Internal

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

Noopur Raje et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

leExploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma

Jie Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Immunology

Updates on CAR T-cell therapy in B-cell malignancies

Elad Jacoby et al.

IMMUNOLOGICAL REVIEWS (2019)

Editorial Material Critical Care Medicine

Understanding tumor lysis syndrome

Lara Zafrani et al.

INTENSIVE CARE MEDICINE (2019)

Review Medical Laboratory Technology

Tumor Lysis Syndrome

Shelly M. Williams et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2019)

Article Hematology

ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells

Daniel W. Lee et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2019)

Article Cell Biology

Doxycycline Inducible Chimeric Antigen Receptor T Cells Targeting CD147 for Hepatocellular Carcinoma Therapy

Ren-Yu Zhang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Oncology

Chimeric antigen receptor T-cell therapy - assessment and management of toxicities

Sattva S. Neelapu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells

Jose Santiago Ibanez-Cabellos et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Biochemistry & Molecular Biology

CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Theodoros Giavridis et al.

NATURE MEDICINE (2018)

Review Biotechnology & Applied Microbiology

Interleukin-6: designing specific therapeutics for a complex cytokine

Christoph Garbers et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Medicine, General & Internal

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

Jae H. Park et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

Epstein-Barr Virus and Hemophagocytic Lymphohistiocytosis

Rebecca A. Marsh

FRONTIERS IN IMMUNOLOGY (2018)

Review Oncology

Cytokine release syndrome

Alexander Shimabukuro-Vornhagen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Article Oncology

Development of NKG2D-based chimeric antigen receptor-T cells for gastric cancer treatment

Kelong Tao et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2018)

Article Oncology

Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy

Erhao Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Review Cell Biology

Driving gene-engineered T cell immunotherapy of cancer

Laura A. Johnson et al.

CELL RESEARCH (2017)

Article Biotechnology & Applied Microbiology

Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers

Chengcheng Zhang et al.

MOLECULAR THERAPY (2017)

Article Biotechnology & Applied Microbiology

Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma

Frederick L. Locke et al.

MOLECULAR THERAPY (2017)

Review Pediatrics

Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome

Claudia Bracaglia et al.

PEDIATRIC RHEUMATOLOGY (2017)

Review Oncology

Mechanisms and risk factors of thrombosis in cancer

Anna Falange et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2017)

Article Pathology

Circulating Extracellular Histones Are Clinically Relevant Mediators of Multiple Organ Injury

Chihiro Kawai et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

Article Biochemistry & Molecular Biology

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

Kole T. Roybal et al.

Article Cardiac & Cardiovascular Systems

Tissue factor as a link between inflammation and coagulation

Marco Witkowski et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2016)

Review Oncology

Engineered T cells: the promise and challenges of cancer immunotherapy

Andrew D. Fesnak et al.

NATURE REVIEWS CANCER (2016)

Article Immunology

G-CSF and GM-CSF in Neutropenia

Hrishikesh M. Mehta et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Urology & Nephrology

Tumor Lysis Syndrome: New Challenges and Recent Advances

F. Perry Wilson et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2014)

Article Medicine, General & Internal

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

Shannon L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Cell Biology

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Marco L. Davila et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Oncology

T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans

Marcela V. Maus et al.

CANCER IMMUNOLOGY RESEARCH (2013)

Review Immunology

Intravenous immunoglobulin therapy: how does IgG modulate the immune system?

Inessa Schwab et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Biotechnology & Applied Microbiology

Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions

Kevin J. Curran et al.

JOURNAL OF GENE MEDICINE (2012)

Article Education, Scientific Disciplines

Approach to Hemophagocytic Syndromes

Sheila Weitzman

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2011)

Article Oncology

Severe Neurologic Side Effects in Patients Being Treated for Hemophagocytic Lymphohistiocytosis

Patrick A. Thompson et al.

PEDIATRIC BLOOD & CANCER (2009)

Review Oncology

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis

Jan-Inge Henter et al.

PEDIATRIC BLOOD & CANCER (2007)

Article Hematology

High-mobility group box 1 protein promotes development of microvascular thrombosis in rats

T. Ito et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)