期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.614294
关键词
cancer systems; immunotherapy; iron metabolism; macrophage polarization; tumor microenvironment
类别
资金
- Carol M. Baldwin Breast Cancer Research Fund
- Stony Brook School of Medicine Departments of Radiology and Pharmacological Sciences
- Bahl Center for Metabolomics and Imaging at the Stony Brook Cancer Center
Macrophages play important roles in systemic iron metabolism and immune response. Infiltration and polarization of macrophages in the tumor microenvironment are associated with cancer prognosis, with distinct iron and immune phenotypes observed in tumor associated macrophages in most cancers. Functional connections between dysfunctional iron metabolism and tumor immune response are emerging, providing new insights for immunometabolic precision therapy approaches.
Macrophages fulfill central functions in systemic iron metabolism and immune response. Infiltration and polarization of macrophages in the tumor microenvironment is associated with differential cancer prognosis. Distinct metabolic iron and immune phenotypes in tumor associated macrophages have been observed in most cancers. While this prompts the hypothesis that macroenvironmental manifestations of dysfunctional iron metabolism have direct associations with microenvironmental tumor immune response, these functional connections are still emerging. We review our current understanding of the role of macrophages in systemic and microenvironmental immune response and iron metabolism and discuss these functions in the context of cancer and immunometabolic precision therapy approaches. Accumulation of tumor associated macrophages with distinct iron pathologies at the invasive tumor front suggests an Iron Curtain presenting as an innate functional interface between systemic and microenvironmental iron metabolism and immune response that can be harnessed therapeutically to further our goal of treating and eliminating cancer.
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