期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.666388
关键词
HIV-2; ART; CTL; TSCM cells; TFH cells; CXCR5+CD8+cells; B cells
类别
资金
- Department of Health Research (Human Resource Development Young Scientist Fellowship)
- Indian Council of Medical Research, Govt. of India
CD4(+) T cells including Tfh and Tscm subsets play a crucial role in producing neutralizing antibodies, controlling virus replication, and slowing disease progression.
CD4(+) T cells are critical players in the host adaptive immune response. Emerging evidence suggests that certain CD4(+) T cell subsets contribute significantly to the production of neutralizing antibodies and help in the control of virus replication. Circulating T follicular helper cells (Tfh) constitute a key T cell subset that triggers the adaptive immune response and stimulates the production of neutralizing antibodies (NAbs). T cells having stem cell-like property, called stem-like memory T cells (Tscm), constitute another important subset of T cells that play a critical role in slowing the rate of disease progression through the differentiation and expansion of different types of memory cell subsets. However, the role of these immune cell subsets in T cell homeostasis, CD4(+) T cell proliferation, and progression of disease, particularly in HIV-2 infection, has not yet been elucidated. The present study involved a detailed evaluation of the different CD4(+) T cell subsets in HIV-2 infected persons with a view to understanding the role of these immune cell subsets in the better control of virus replication and delayed disease progression that is characteristic of HIV-2 infection. We observed elevated levels of CD4(+) Tfh and CD4(+) Tscm cells along with memory and effector T cell abundance in HIV-2 infected individuals. We also found increased frequencies of CXCR5(+) CD8(+) T cells and CD8(+) Tscm cells, as well as memory B cells that are responsible for NAb development in HIV-2 infected persons. Interestingly, we found that the frequency of memory CD4(+) T cells as well as memory B cells correlated significantly with neutralizing antibody titers in HIV-2 infected persons. These observations point to a more robust CD4(+) T cell response that supports B cell differentiation, antibody production, and CD8(+) T cell development in HIV-2 infected persons and contributes to better control of the virus and slower rate of disease progression in these individuals.
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