期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.670290
关键词
IgA antibodies; plasma cell (PC); inflammation; mucosal immunity; autoimmunity; gut-associated lymphoid tissues (GALT)
类别
资金
- Technical University Munich (TUM)
- German Research Foundation (DFG) [Ke1737/2-1]
- ElseKroner-Fresenius-Stiftung grant [2019_A105]
Humoral immunity is mediated by ASC specialized in synthesizing antibodies, with over 80% residing in the gut and most expressing IgA. These antibodies play a crucial role in maintaining intestinal homeostasis and protective immunity, while also being involved in immune responses outside of mucosal tissues.
Humoral immunity is mainly mediated by a B cell population highly specialized to synthesize and secrete large quantities of antibodies - the antibody-secreting cells (ASC). In the gastrointestinal environment, a mixture of foreign antigens from the diet, commensal microbiota as well as occasional harmful pathogens lead to a constant differentiation of B cells into ASC. Due to this permanent immune response, more than 80% of mammalian ASC reside in the gut, of which most express immunoglobulin A (IgA). IgA antibodies contribute to intestinal homeostasis and can mediate protective immunity. Recent evidence points at a role for gut-derived ASC in modulating immune responses also outside of mucosal tissues. We here summarize recent evidence for wandering ASC, their antibodies and their involvement in systemic immune responses.
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