4.8 Review

Human Herpesviruses 6A and 6B in Reproductive Diseases

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Summary: This study used advanced sequencing technology and mining of public human genome datasets to comprehensively understand the evolution of HHV-6, revealing that heritable integration of HHV-6 has existed since human migrations out of Africa. The research also showed that circulating and integrated HHV-6A and HHV-6B have distinct evolutionary histories and characteristics.

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Summary: Inherited chromosomally integrated HHV-6 (iciHHV-6) can be transmitted from parent to child and is associated with increased risk of spontaneous abortion, especially in mothers who are iciHHV-6 positive and those who are ≥40 years old at their most recent pregnancy.

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Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation

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Summary: This review examines the evidence that Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B) may trigger neurological diseases in humans, including encephalitis in immunocompromised patients and febrile seizures in infants and children. It also discusses the criteria for linking infectious agents to neurologic diseases and evaluates the extent to which these criteria have been met for HHV-6A/B and various neurological conditions.

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Unbiased optical mapping of telomere-integrated endogenous human herpesvirus 6

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HHV-6A Infection of Endometrial Epithelial Cells Affects miRNA Expression and Trophoblast Cell Attachment

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Article Obstetrics & Gynecology

What exactly is endometrial receptivity?

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HUMAN HERPESVIRUS 6A AND 6B AND NK CELLS

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Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections

Henri Agut et al.

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Annie Gravel et al.

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Evidence of human herpesvirus-6 and-7 reactivation in miscarrying women with pityriasis rosea

Francesco Drago et al.

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Pre-eclampsia part 1: current understanding of its pathophysiology

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Pre-eclampsia part 2: prediction, prevention and management

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Chromosomally integrated HHV-6: impact on virus, cell and organismal biology

Benedikt B. Kaufer et al.

CURRENT OPINION IN VIROLOGY (2014)

Review Virology

Chromosomally integrated human herpesvirus 6: questions and answers

Philip E. Pellett et al.

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The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells

Roberta Rizzo et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Article Obstetrics & Gynecology

Assessment of endometrial receptivity

Bruce A. Lessey

FERTILITY AND STERILITY (2011)

Article Immunology

The etiology of preeclampsia: the role of the father

Gus Dekker et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2011)

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Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

Erin Harberts et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Transplacental Congenital Human Herpesvirus 6 Infection Caused by Maternal Chromosomally Integrated Virus

Caroline Breese Hall et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

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Infectious Disease and Reproductive Health A Review

Laura E. Baecher-Lind et al.

OBSTETRICAL & GYNECOLOGICAL SURVEY (2010)

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Febrile Seizures and Primary Human Herpesvirus 6 Infection

Ioanna Laina et al.

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The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro

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U94 of human herpesvirus 6 inhibits in vitro angiogenesis and lymphangiogenesis

Arnaldo Caruso et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Maternal infection and risk of preeclampsia: Systematic review and metaanalysis

Agustin Conde-Agudelo et al.

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Fetal exposure to herpesviruses may be associated with pregnancy-induced hypertensive disorders and preterm birth in a Caucasian population

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Human herpesvirus (HHV)-6 and HHV-7 infections in pregnant women

Mary T. Caserta et al.

JOURNAL OF INFECTIOUS DISEASES (2007)

Article Cell Biology

PKR-dependent autophagic degradation of herpes simplex virus type 1

Zsolt Talloczy et al.

AUTOPHAGY (2006)

Review Clinical Neurology

Role of viral infections in the etiology of febrile seizures

J. Gordon Millichap et al.

PEDIATRIC NEUROLOGY (2006)

Article Immunology

Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A

S Meeuwsen et al.

JOURNAL OF NEUROIMMUNOLOGY (2005)

Review Microbiology

Update on human herpesvirus 6 biology, clinical features, and therapy

L De Bolle et al.

CLINICAL MICROBIOLOGY REVIEWS (2005)

Article Virology

Reactivation of human herpesvirus 6 and 7 in pregnant women

M Ohashi et al.

JOURNAL OF MEDICAL VIROLOGY (2002)

Article Peripheral Vascular Disease

Pathophysiology of pregnancy-induced hypertension

JP Granger et al.

AMERICAN JOURNAL OF HYPERTENSION (2001)

Letter Microbiology

Human herpesvirus 6 infects and replicates in aortic endothelium

A Rotola et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2000)

Article Virology

Epidemiology of human herpesvirus 6 (HHV-6) infection in pregnant and nonpregnant women

J Baillargeon et al.

JOURNAL OF CLINICAL VIROLOGY (2000)