期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.659761
关键词
lineage-specific transcription factor; chromatin architecture; enhancer; Rag1 and Rag2 gene; super-enhancer; 3D genome organization
类别
资金
- KAKENHI
- MEXT of Japan [19H03487]
- Mochida Memorial Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [19H03487] Funding Source: KAKEN
This article discusses the driving factors of cell type-specific gene expression, emphasizing the importance of the interplay between chromatin architectures and TFs in cell fate decisions and cell type-specific functions, as well as the key roles of SEs and Rag1/2 genes in adaptive immunity.
Cell type-specific gene expression is driven through the interplay between lineage-specific transcription factors (TFs) and the chromatin architecture, such as topologically associating domains (TADs), and enhancer-promoter interactions. To elucidate the molecular mechanisms of the cell fate decisions and cell type-specific functions, it is important to understand the interplay between chromatin architectures and TFs. Among enhancers, super-enhancers (SEs) play key roles in establishing cell identity. Adaptive immunity depends on the RAG-mediated assembly of antigen recognition receptors. Hence, regulation of the Rag1 and Rag2 (Rag1/2) genes is a hallmark of adaptive lymphoid lineage commitment. Here, we review the current knowledge of 3D genome organization, SE formation, and Rag1/2 gene regulation during B cell and T cell differentiation.
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