期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.639329
关键词
COVID-19; SARS-CoV-2 infection; T cell trafficking; integrins; gut homing
类别
资金
- German Research Foundation (DFG) [ZU 377/4-1, TRR241TP C04]
- Interdisciplinary Center for Clinical Research (IZKF) of the University Erlangen-Nuremberg [J63, A84]
- Wilhelm Sander-Stiftung [2020.045.1]
- Bayerische Forschungsforderung
- Bavarian State Ministry for Sciences and Art [TP-10, TP-11]
- National research network for University Medicine (NUM)
COVID-19 is associated with a decrease in circulating adaptive immune cells expressing the key gut homing marker alpha 4 beta 7, while the total number of IgA-expressing B cells is increased. This suggests that the systemic immune response against SARS-CoV-2 may be dominated by extraintestinal, particularly pulmonary, immune cell priming.
Background Infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a wide range of symptoms including gastrointestinal manifestations, and intestinal epithelial cells are a target of the virus. However, it is unknown how the intestinal immune system contributes to systemic immune responses in coronavirus disease 2019 (COVID-19). Methods We characterized peripheral blood lymphocytes from patients with active COVID-19 and convalescent patients as well as healthy controls by flow cytometry. Results The frequency and absolute number of circulating memory T and B cells expressing the gut homing integrin alpha 4 beta 7 integrin was reduced during COVID-19, whether gastrointestinal symptoms were present or not. While total IgA-expressing B cells were increased, gut-imprinted B cells with IgA expression were stable. Conclusion COVID-19 is associated with a decrease in circulating adaptive immune cells expressing the key gut homing marker alpha 4 beta 7 suggesting that these cells are preferentially recruited to extra-intestinal tissues independently of alpha 4 beta 7 or that the systemic immune response against SARS-CoV-2 is at least numerically dominated by extraintestinal, particularly pulmonary, immune cell priming.
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