4.8 Article

Transcriptional Profiles of Genes Related to Stress and Immune Response in Rainbow Trout (Oncorhynchus mykiss) Symptomatically or Asymptomatically Infected With Vibrio anguillarum

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Article Fisheries

Identification and characterization of caspases genes in rainbow trout (Oncorhynchus mykiss) and their expression profiles after Aeromonas salmonicida and Vibrio anguillarum infection

Chu Zeng et al.

Summary: In rainbow trout, 18 caspase genes were identified, with different roles observed in response to Aeromonas salmonicida and Vibrio anguillarum infections. CASP3-regulated intrinsic apoptosis was activated after A. salmonicida infection, while CASP8 and CASP6-regulated extrinsic apoptosis had the greatest effect on trout challenged with V. anguillarum. RNA-Seq data showed the integration of casp8 with significantly enriched Gene Ontology terms and functional pathways in response to V. anguillarum infection, including apoptosis regulation, pathogen detection, and immunomodulation.

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