期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.675476
关键词
COVID-19; pregnant women; immune response; lymphocyte subtypes; cytokines
类别
资金
- National Key Research and Development Program [2019YFC1005200, 2019YFC1005202]
- Hubei Province Health and Family Planning Scientific Research Project [WJ2019M127]
Pregnant patients with COVID-19 exhibit an enhanced innate immune response with higher levels of neutrophils and C-reactive protein, while non-pregnant patients during the same period show suppressed cytokine storm. This may contribute to the unique anti-SARS-CoV-2 response in pregnant patients.
Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 on pregnant women remains to be determined, evidence indicates that risks of adverse clinical outcomes are similar in pregnancy to the general population. Here we analyzed clinical symptoms and outcomes of 20 pregnant and 299 reproductive-aged non-pregnant female COVID-19 patients who were hospitalized during the same period. Laboratory measurements were compared among mild cases and healthy pregnant women. Our study found that pregnant patients showed enhanced innate immune response evident by higher neutrophils and C-reactive protein. Cytokines, chemokines, and growth factors (CCGFs) profiles from 11 pregnant and 4 non-pregnant COVID-19 patients and 10 healthy pregnant female patients, and lymphocyte subsets analysis of 7 pregnant patients and 19 non-pregnant patients, indicate suppressed cytokine storm and potential enhanced CD8+ T cell and NK cell activity in pregnant patients with COVID-19, which may be essential in contributing to the unique anti-SARS-CoV-2 response in pregnancy.
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