期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
卷 8, 期 5, 页码 398-404出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.estlett.1c00184
关键词
-
资金
- NSF RAPID [CBET-2023057]
Published and unpublished reports indicate that SARS-CoV-2 RNA in POTW wastewater is associated with new COVID-19 cases, and using the concentrations of SARS-CoV-2 N1 and N2 normalized by PMMoV RNA in solids can help compare incidence of laboratory confirmed COVID-19 cases across different systems, supporting the application of wastewater-based epidemiology in response to the pandemic.
Published and unpublished reports show that SARS-CoV-2 RNA in publicly owned treatment work (POTW) wastewater influent and solids is associated with new COVID-19 cases or incidence in associated sewersheds, but methods for comparing data collected from diverse POTWs to infer information about the relative incidence of laboratory-confirmed COVID-19 cases, and scaling to allow such comparisons, have not been previously established. Here, we show that SARS-CoV-2 N1 and N2 concentrations in solids normalized by concentrations of PMMoV RNA in solids can be used to compare incidence of laboratory confirmed new COVID-19 cases across POTWs. Using data collected at seven POTWs along the United States West Coast, Midwest, and East Coast serving similar to 3% of the U.S. population (9 million people), we show that a 1 log change in N gene/PMMoV is associated with a 0.24 (range 0.19 to 0.29) log(10) change in incidence of laboratory confirmed COVID-19. Scaling of N1 and N2 by PMMoV is consistent, conceptually, with a mass balance model relating SARS-CoV-2 RNA to the number of infected individuals shedding virus in their stool. This information should support the application of wastewater-based epidemiology to inform the response to the COVID-19 pandemic and potentially future viral pandemics.
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