期刊
ACS INFECTIOUS DISEASES
卷 7, 期 7, 页码 2013-2024出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.1c00066
关键词
antiplasmodium; antimalarial; artemsinin; endoperoxide; artemisinin dimers
资金
- National Institutes of Health [R01AI090662, R01AI144464]
- Georgia Research Alliance
Research focuses on the antimalarial activity of artemisinin dimers, particularly the increase in activity of artemisinin moieties and the impact of deactivation caused by degradation of the peroxide bridge.
During the past decade, artemisinin as an antimalarial has been in the spotlight, in part due to the Nobel Prize in Physiology or Medicine awarded to Tu Youyou. While many studies have been completed detailing the significant increase in activity resulting from the dimerization of natural product artemisinin, activity increases unaccounted for by the peroxide bridge have yet to be researched. Here we outline the synthesis and testing for antimalarial activity of artemisinin dimers in which the peroxide bridge in one-half of the dimer is reduced, resulting in a dimer with one active and one deactivated artemisinin moiety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据