期刊
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
卷 17, 期 -, 页码 259-266出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/TCRM.S298156
关键词
dry eye disease; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; case-control study; risk factor
资金
- National Natural Science Foundation Project for Young Scientists of China [81700804]
- Foundation for Young Medical Talents of Jiangsu Province [QNRC2016211]
- Scientific Research Project of Jiangsu Health Commission [Z2019044]
In this study, it was found that the NLR value of DED patients was higher compared to healthy controls, while the PLR did not show significant differences. Furthermore, DED cases with high NLR values exhibited more severe symptoms in terms of TBUT, CFS, and OSDI scores.
Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been used as indicators of inflammation, however, their roles in dry eye disease (DED) patients require advanced study Materials and Methods: A total of 104 DED cases and 97 healthy controls from January 2020 to May 2020 were enrolled in this study. The dry eye related clinical variables, including Schirmer I test, tear break-up time (TBUT), corneal fluorescein staining (CFS) and Ocular Surface Disease Index (OSDI), were detected in all the participants. Besides, the NLR and PLR pattern in DED cases were detected and their potential value as inflammatory predictors of DED were evaluated. In advanced analyses, the correlation between NLR and DED severity was examined. Results: The NLR and PLR were 2.59 +/- 1.25 and 117.48 +/- 54.68 in the DED group, respectively, while they were 2.20 +/- 1.24 and 115.48 +/- 54.33 in the control group, respectively. The NLR was higher in the DED group (p = 0.027), however, PLR was not significantly different compared with the control group (p = 0.951). In advanced analyses, it was found that more severe TBUT, CFS, and OSDI scores were detected in the high NLR group (NLR >= 2.145, p = 0.003, 0.013, and 0.017, respectively) compared with the low NLR group (NLR <2.145). Conclusion: The NLR value, but not PLR, of DED patients was higher than that of healthy controls. The NLR could be used as an inflammatory predictor to estimate the severity of DED.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据