期刊
STEM CELL REPORTS
卷 16, 期 5, 页码 1117-1141出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2021.03.019
关键词
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资金
- MRC [MCA652-5QA10]
- BBSRC [BB/R002703/1]
- National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC)
- Ragnar Soderberg Foundation
- ERC grant [772798]
- Ming Wai Lau Center for Reparative Medicine
- Center for Individualized Medicine, Mayo Clinic
- Wallenberg Academy Fellow
- Strategic Research Area (SRA) Stem Cells and Regenerative Medicine
- European Research Council (ERC) [772798] Funding Source: European Research Council (ERC)
- BBSRC [BB/R002703/1] Funding Source: UKRI
Studying embryos provides a mechanistic understanding of development with relevance to human disease. In vitro cultured stem cell models offer an alternative for studying embryo development, but their usefulness depends on how accurately they reflect in vivo embryonic development.
Detailed studies of the embryo allow an increasingly mechanistic understanding of development, which has proved of profound relevance to human disease. The last decade has seen in vitro cultured stem cell-based models of embryo development flourish, which provide an alternative to the embryo for accessible experimentation. However, the usefulness of any stem cell-based embryo model will be determined by how accurately it reflects in vivo embryonic development, and/or the extent to which it facilitates new discoveries. Stringent benchmarking of embryo models is thus an important consideration for this growing field. Here we provide an overview of means to evaluate both the properties of stem cells, the building blocks of most embryo models, as well as the usefulness of current and future in vitro embryo models.
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