期刊
NANOMATERIALS
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/nano11040945
关键词
metal-organic frameworks nanoparticles; doxorubicin; cyclodextrin; solid state NMR spectroscopy
类别
资金
- French National Research Agency (ANR) as part of the Investissements d'Avenir program (Labex NanoSaclay) [ANR-10-LABX-0035]
- Region Centre-Val de Loire
- Institut Universitaire de France (IUF)
- IR-RMN-THC Fr3050 CNRS
- Paris Ile-de-France Region-DIM Respore
Recent development of nanoscale metal-organic frameworks with versatile coatings has attracted attention in nanomedicine field. The preparation of core-shell MIL-100(Al) nanoMOFs for delivering the anticancer drug DOX and the affinity of the coatings for both DOX and MOF cores were demonstrated. Solid state nuclear magnetic resonance experiments were used to gain understanding on the interactions in the core-shell system.
Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Here we show the preparation of core-shell MIL-100(Al) nanoMOFs for the delivery of the anticancer drug doxorubicin (DOX). DOX was efficiently incorporated in the MOFs and was released in a progressive manner, depending on the initial loading. Besides, the coatings were made of biodegradable gamma-cyclodextrin-citrate oligomers (CD-CO) with affinity for both DOX and the MOF cores. DOX was incorporated and released faster due to its affinity for the coating material. A set of complementary solid state nuclear magnetic resonance (ssNMR) experiments including H-1-H-1 and C-13-Al-27 two-dimensional NMR, was used to gain a deep understanding on the multiple interactions involved in the MIL-100(Al) core-shell system. To do so, C-13-labelled shells were synthesized. This study paves the way towards a methodology to assess the nanoMOF component localization at a molecular scale and to investigate the nanoMOF physicochemical properties, which play a main role on their biological applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据