期刊
NANOMATERIALS
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/nano11040947
关键词
pillar[5]arene; tetrazole; drug delivery systems; fluorescein
类别
资金
- Russian Science Foundation [20-73-00161]
- Russian Federation [NSh-2499.2020.3]
- Russian Science Foundation [20-73-00161] Funding Source: Russian Science Foundation
This study introduces a novel universal stimulus-sensitive nanosized polymer system based on decasubstituted macrocyclic structures-pillar[5]arenes and tetrazole-containing polymers. The system shows significant fluorescence enhancement under acidic conditions, indicating potential applications in the development of new drug delivery systems.
In this work, we have proposed a novel universal stimulus-sensitive nanosized polymer system based on decasubstituted macrocyclic structures-pillar[5]arenes and tetrazole-containing polymers. Decasubstituted pillar[5]arenes containing a large, good leaving tosylate, and phthalimide groups were first synthesized and characterized. Pillar[5]arenes containing primary and tertiary amino groups, capable of interacting with tetrazole-containing polymers, were obtained with high yield by removing the tosylate and phthalimide protection. According to the fluorescence spectroscopy data, a dramatic fluorescence enhancement in the pillar[5]arene/fluorescein/polymer system was observed with decreasing pH from neutral (pH = 7) to acidic (pH = 5). This indicates the destruction of associates and the release of the dye at a pH close to 5. The presented results open a broad range of opportunities for the development of new universal stimulus-sensitive drug delivery systems containing macrocycles and nontoxic tetrazole-based polymers.
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