4.6 Review

Human coronaviruses and therapeutic drug discovery

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Review Virology

Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis

Dong Huang et al.

Summary: The study evaluated the efficacy and safety of umifenovir in COVID-19, indicating some effectiveness in certain aspects but failing to demonstrate improvement in important patient outcomes.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Medicine, General & Internal

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia A Randomized Clinical Trial

Carlo Salvarani et al.

Summary: This study evaluated the use of tocilizumab in hospitalized COVID-19 pneumonia patients and found no significant benefit compared to standard care. Further randomized clinical trials with blinded, placebo-controlled methods are needed to confirm these results and explore potential applications of tocilizumab in different stages of the disease.

JAMA INTERNAL MEDICINE (2021)

Editorial Material Medicine, General & Internal

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

Clark D. Russell et al.

LANCET (2020)

Review Rheumatology

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

Eva Schrezenmeier et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Infectious Diseases

Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19

Zhen Zhu et al.

JOURNAL OF INFECTION (2020)

Article Medicine, General & Internal

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

Jason D. Goldman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis

Jonathan A. C. Sterne et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 A Randomized Clinical Trial

Christoph D. Spinner et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Biochemistry & Molecular Biology

Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study

Sean T. H. Liu et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

John H. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Pharmacology & Pharmacy

Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors

Nashwa Hafez Zaher et al.

ACTA PHARMACEUTICA (2020)

Letter Biochemistry & Molecular Biology

A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia

Yin Wang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Multidisciplinary Sciences

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

Shuai Xia et al.

SCIENCE ADVANCES (2019)

Review Microbiology

Human Coronavirus: Host-Pathogen Interaction

To Sing Fung et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 73 (2019)

Article Medicine, Research & Experimental

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

Rudragouda Channappanavar et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Chemistry, Medicinal

Design, Synthesis, and Anti-RNA Virus Activity of 6′-Fluorinated-Aristeromycin Analogues

Ji-seong Yoon et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors

Seri Jo et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2019)

Article Pharmacology & Pharmacy

Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

Min-Han Lin et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

Christin Mueller et al.

ANTIVIRAL RESEARCH (2018)

Article Chemistry, Medicinal

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

Anushka C. Galasiti Kankanamalage et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains

Shuai Xia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Chemistry, Medicinal

Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents

Konstantina Karypidou et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Cell Biology

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Review Pharmacology & Pharmacy

T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV

William J. Liu et al.

ANTIVIRAL RESEARCH (2017)

Article Chemistry, Medicinal

Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor

Hiroyuki Konno et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Infectious Diseases

Effective inhibition of MERS-CoV infection by resveratrol

Shih-Chao Lin et al.

BMC INFECTIOUS DISEASES (2017)

Article Biochemistry & Molecular Biology

Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV

Ji-Young Park et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2016)

Review Biotechnology & Applied Microbiology

Coronaviruses - drug discovery and therapeutic options

Alimuddin Zumla et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Review Biochemistry & Molecular Biology

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

Shuo Su et al.

TRENDS IN MICROBIOLOGY (2016)

Article Immunology

Antibody Response and Disease Severity in Healthcare Worker MERS Survivors

Abeer N. Alshukairi et al.

EMERGING INFECTIOUS DISEASES (2016)

Article Pharmacology & Pharmacy

Protease inhibitors targeting coronavirus and filovirus entry

Yanchen Zhou et al.

ANTIVIRAL RESEARCH (2015)

Review Pharmacology & Pharmacy

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

Yahira M. Baez-Santos et al.

ANTIVIRAL RESEARCH (2015)

Article Chemistry, Medicinal

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

Hannah L. Peters et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Article Multidisciplinary Sciences

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

Davide Corti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

Kristen E. Pascal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Mathematical & Computational Biology

Design of Potential RNAi (miRNA and siRNA) Molecules for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Gene Silencing by Computational Method

Suza Mohammad Nur et al.

INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES (2015)

Review Pharmacology & Pharmacy

Arbidol as a broad-spectrum antiviral: An update

Julie Blaising et al.

ANTIVIRAL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia

Dae Wook Kim et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2014)

Article Biotechnology & Applied Microbiology

Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

Brit J. Hart et al.

JOURNAL OF GENERAL VIROLOGY (2014)

Article Multidisciplinary Sciences

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

Travis K. Warren et al.

NATURE (2014)

Article Multidisciplinary Sciences

Rapid generation of a mouse model for Middle East respiratory syndrome

Jincun Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

Shihui Sun et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Dieckol, a SARS-CoV 3CLpro inhibitor, isolated, from the edible brown algae Ecklonia cava

Ji-Young Park et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2013)

Article Biotechnology & Applied Microbiology

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Adriaan H. de Wilde et al.

JOURNAL OF GENERAL VIROLOGY (2013)

Article Pharmacology & Pharmacy

Diarylheptanoids from Alnus japonica Inhibit Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus

Ji-Young Park et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2012)

Article Biochemistry & Molecular Biology

Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases

Ji-Young Park et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Broad-Spectrum Antiviral Therapeutics

Todd H. Rider et al.

PLOS ONE (2011)

Article Business

Literature-related discovery: Potential treatments and preventatives for SARS

Ronald N. Kostoff

TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE (2011)

Article Chemistry, Medicinal

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

Young Bae Ryu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Multidisciplinary Sciences

A broad-spectrum antiviral targeting entry of enveloped viruses

Mike C. Wolf et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Chemistry, Medicinal

Aryl diketoacids (ADK) selectively inhibit duplex DNA-unwinding activity of SARS coronavirus NTPase/helicase

Chaewoon Lee et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Plant Sciences

Immunomodulatory and anti-SARS activities of Houttuynia cordata

Kit-Man Lau et al.

JOURNAL OF ETHNOPHARMACOLOGY (2008)

Review Chemistry, Medicinal

Antiviral effects of Glycyrrhiza species

Cristina Fiore et al.

PHYTOTHERAPY RESEARCH (2008)

Article Biochemistry & Molecular Biology

Studies on the interactions of Ti-containing polyoxometalates (POMs) with SARS-CoV 3CL(pro) by molecular modeling

Donghua Hu et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2007)

Article Chemistry, Medicinal

Antiviral activity of glycyrrhizic acid derivatives against SARS - Coronavirus

G Hoever et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Pharmacology & Pharmacy

Inhibition of SARS-CoV replication by siRNA

CJ Wu et al.

ANTIVIRAL RESEARCH (2005)

Article Biochemistry & Molecular Biology

Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference

YJ Zhang et al.

FEBS LETTERS (2004)

Article Medicine, General & Internal

Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets

J ter Meulen et al.

LANCET (2004)

Article Medicine, General & Internal

Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area

CM Booth et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)