4.6 Article

The Arabidopsis JMJ29 Protein Controls Circadian Oscillation through Diurnal Histone Demethylation at the CCA1 and PRR9 Loci

期刊

GENES
卷 12, 期 4, 页码 -

出版社

MDPI
DOI: 10.3390/genes12040529

关键词

circadian clock; evening complex; histone methylation; JMJ29; CCA1; PRR9

资金

  1. National Research Foundation of Korea [NRF-2019R1A2C2006915, NRF-2020R1A4A2002901]
  2. Creative-Pioneering Researchers Program of Seoul National University [0409-20200281]

向作者/读者索取更多资源

The study reveals that the interaction between JMJ29 protein and the Evening Complex (EC) component ELF3 leads to rhythmic changes in H3K4me3 histone marks at core clock loci in plants. This interaction helps maintain a low-level expression of CCA1 and PRR9 promoters during the evening time.
The circadian clock matches various biological processes to diurnal environmental cycles, such as light and temperature. Accumulating evidence shows that chromatin modification is crucial for robust circadian oscillation in plants, although chromatin modifiers involved in regulating core clock gene expression have been limitedly investigated. Here, we report that the Jumonji C domain-containing histone demethylase JMJ29, which belongs to the JHDM2/KDM3 group, shapes rhythmic changes in H3K4me3 histone marks at core clock loci in Arabidopsis. The evening-expressed JMJ29 protein interacts with the Evening Complex (EC) component EARLY FLOWERING 3 (ELF3). The EC recruits JMJ29 to the CCA1 and PRR9 promoters to catalyze the H3K4me3 demethylation at the cognate loci, maintaining a low-level expression during the evening time. Together, our findings demonstrate that interaction of circadian components with chromatin-related proteins underlies diurnal fluctuation of chromatin structures to maintain circadian waveforms in plants.

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