期刊
FRONTIERS IN PHYSIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.669279
关键词
CD36; dietary lipid; intestine; lipid homeostasis; intestinal hormones
类别
资金
- National Natural Science Foundation of China [32030054, 81970510, 31971084]
- Talent Project of Chongqing [CQYC2019050790]
- Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN201900438]
- 111 Project of China [D20028]
- National Key R&D Program of China [2018YFC1312700]
Intestinal CD36 plays a vital role in regulating intestinal lipid uptake and hormone secretion, but further studies are needed to confirm its complex interactions with dietary lipids.
Dietary lipids absorbed in the intestine are closely related to the development of metabolic syndrome. CD36 is a multi-functional scavenger receptor with multiple ligands, which plays important roles in developing hyperlipidemia, insulin resistance, and metabolic syndrome. In the intestine, CD36 is abundant on the brush border membrane of the enterocytes mainly localized in proximal intestine. This review recapitulates the update and current advances on the importance of intestinal CD36 in sensing dietary lipids and regulating intestinal lipids uptake, synthesis and transport, and regulating intestinal hormones secretion. However, further studies are still needed to demonstrate the complex interactions between intestinal CD36 and dietary lipids, as well as its importance in diet associated metabolic syndrome.
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