The Hepatic Monocarboxylate Transporter 1 (MCT1) Contributes to the Regulation of Food Anticipation in Mice

Daily recurring events can be predicted by animals based on their internal circadian timing system. However, independently from the suprachiasmatic nuclei (SCN), the central pacemaker of the circadian system in mammals, restriction of food access to a particular time of day elicits food anticipatory activity (FAA). This suggests an involvement of other central and/or peripheral clocks as well as metabolic signals in this behavior. One of the metabolic signals that is important for FAA under combined caloric and temporal food restriction is beta-hydroxybutyrate (beta OHB). Here we show that the monocarboxylate transporter 1 (Mct1), which transports ketone bodies such as beta OHB across membranes of various cell types, is involved in FAA. In particular, we show that lack of the Mct1 gene in the liver, but not in neuronal or glial cells, reduces FAA in mice. This is associated with a reduction of beta OHB levels in the blood. Our observations suggest an important role of ketone bodies and its transporter Mct1 in FAA under caloric and temporal food restriction.

Automated summary

Animals can predict daily recurring events through their internal circadian timing system, and food restriction to a specific time can induce food anticipatory activity (FAA). Research has shown that the role of Mct1 in the liver has a significant impact on FAA in mice, which is associated with blood levels of beta OHB.