期刊
FRONTIERS IN PHYSIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.640061
关键词
angiogenesis; embryo; cell cycle; autophagy; inflammation
类别
资金
- AIRC-Associazione Italiana Per la Ricerca sul Cancro [22910]
- Regione Piemonte [A1907A]
- Ministero dell'Universita e della Ricerca (PRIN 2017) [2017237P5X]
- Fondazione CRT
- FPRC 5xmille 2016 MIUR (Biofilm)
- ERA-Net Transcan-2 [TRS-2018-00000689]
TFEB is an emerging player in vascular biology, involved in various cellular functions including stress adaptation, cell proliferation, metabolism, inflammation, and immunity. In the vascular system, TFEB plays a regulatory role in angiogenesis and is implicated in inflammation and atherosclerosis.
Transcription factor EB (TFEB) represents an emerging player in vascular biology. It belongs to the bHLH-leucine zipper transcription factor microphthalmia family, which includes microphthalmia-associated transcription factor, transcription factor E3 and transcription factor EC, and is known to be deregulated in cancer. The canonical transcriptional pathway orchestrated by TFEB adapts cells to stress in all kinds of tissues by supporting lysosomal and autophagosome biogenesis. However, emerging findings highlight that TFEB activates other genetic programs involved in cell proliferation, metabolism, inflammation and immunity. Here, we first summarize the general principles and mechanisms by which TFEB activates its transcriptional program. Then, we analyze the current knowledge of TFEB in the vascular system, placing particular emphasis on its regulatory role in angiogenesis and on the involvement of the vascular unit in inflammation and atherosclerosis.
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